HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 293/2/R922    most recent 00237.2007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Szentirmai, E. Articles by Krueger, J. M. Search for Related Content PubMed PubMed Citation Articles by Szentirmai, E. Articles by Krueger, J. M.

SLEEP AND TEMPERATURE REGULATION

Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression

¹Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, Washington; ²Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki, Aomori, Japan; ³Division of Basic Medical Sciences and Department of Pediatrics, Mercer University School of Medicine, Macon, Georgia

Submitted 6 April 2007 ; accepted in final form 29 May 2007

Growth hormone-releasing hormone (GHRH), its receptor (GHRHR), and other members of the somatotropic axis are involved in non-rapid eye movement sleep (NREMS) regulation. Previously, studies established the involvement of hypothalamic GHRHergic mechanisms in NREMS regulation, but cerebral cortical GHRH mechanisms in sleep regulation remained uninvestigated. Here, we show that unilateral application of low doses of GHRH to the surface of the rat somatosensory cortex ipsilaterally decreased EEG delta wave power, while higher doses enhanced delta power. These actions of GHRH on EEG delta wave power occurred during NREMS but not during rapid eye movement sleep. Further, the cortical forms of GHRH and GHRHR were identical to those found in the hypothalamus and pituitary, respectively. Cortical GHRHR mRNA and protein levels did not vary across the day-night cycle, whereas cortical GHRH mRNA increased with sleep deprivation. These results suggest that cortical GHRH and GHRHR have a role in the regulation of localized EEG delta power that is state dependent, as well as in their more classic hypothalamic role in NREMS regulation.

non-rapid eye movement sleep; somatotropic axis; sleep deprivation; slow-wave activity

This article has been cited by other articles:

				Z. Peterfi, G. B. Makara, F. Obal Jr., and J. M. Krueger The anterolateral projections of the medial basal hypothalamus affect sleep Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1228 - R1238. [Abstract] [Full Text] [PDF]