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APPETITE, OBESITY, DIGESTION, AND METABOLISM

Long-term consequences of maternal high-fat feeding on hypothalamic leptin sensitivity and diet-induced obesity in the offspring

¹Université Paris–Sud, UMR 1197, Neurobiologie de l'Olfaction et de la Prise Alimentaire, Neuroendocrinologie Moléculaire de la Prise Alimentaire, Orsay; ²Institut National de la Recherche Agronomique, UMR 1197, Jouy-en-Josas; ³Institut National de la Santé et de la Recherche Médicale, Orsay; ⁴Centre National de la Recherche Scientifique, Orsay, France; and ⁵The Hebrew University of Jerusalem, Rehovot, Israel

Submitted 15 February 2007 ; accepted in final form 5 June 2007

Epidemiological and animal studies suggest that the alteration of hormonal and metabolic environment during fetal and neonatal development can contribute to development of metabolic syndrome in adulthood. In this paper, we investigated the impact of maternal high-fat (HF) diet on hypothalamic leptin sensitivity and body weight gain of offspring. Adult Wistar female rats received a HF or a control normal-fat (C) diet for 6 wk before gestation until the end of the suckling period. After weaning, pups received either C or HF diet during 6 wk. Body weight gain and metabolic and endocrine parameters were measured in the eight groups of rats formed according to a postweaning diet, maternal diet, and gender. To evaluate hypothalamic leptin sensitivity in each group, STAT-3 phosphorylation was measured in response to leptin or saline intraperitoneal bolus. Pups exhibited similar body weights at birth, but at weaning, those born to HF dams weighed significantly less (–12%) than those born to C dams. When given the HF diet, males and females born to HF dams exhibited smaller body weight and feed efficiency than those born to C dams, suggesting increased energy expenditure programmed by the maternal HF diet. Thus, maternal HF feeding could be protective against adverse effects of the HF diet as observed in male offspring of control dams: overweight (+17%) with hyperleptinemia and hyperinsulinemia. Furthermore, offspring of HF dams fed either C or HF diet exhibited an alteration in hypothalamic leptin-dependent STAT-3 phosphorylation. We conclude that maternal high-fat diet programs a hypothalamic leptin resistance in offspring, which, however, fails to increase the body weight gain until adulthood.

leptin resistance; hypothalamus; high-fat diet

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