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DEVELOPMENTAL PHYSIOLOGY AND PREGNANCY

Protein restriction in lactation confers nephroprotective effects in the male rat and is associated with increased antioxidant expression

Jane L. Tarry-Adkins,¹ Jaap A. Joles,² Jian-Hua Chen,¹ Malgorzata S. Martin-Gronert,¹ Dionne M. van der Giezen,³ Roel Goldschmeding,³ C. Nicholas Hales,^1, and Susan E. Ozanne¹

¹Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Cambridge, United Kingdom; and ²Departments of Nephrology and Hypertension and ³Pathology, University Medical Centre, Utrecht, The Netherlands

Submitted 5 April 2007 ; accepted in final form 14 June 2007

Telomere shortening has been implicated in the aging process and various age-associated disorders, including renal disease. Moreover, oxidative stress has been identified as an initiator of accelerated telomere shortening. We have shown previously that maternal protein restriction during lactation leads to reduced renal telomere shortening, reduced albuminuria, and increased longevity in rats. Here we address the hypothesis that maternal protein restriction during lactation is nephroprotective and associated with increased expression of antioxidative enzymes and decreased age-dependent renal telomere shortening. Newborn rats were suckled by a dam fed either a control (20% protein) or low-protein (8% protein) diet. All animals were weaned onto standard chow. Offspring that had been suckled by protein-restricted mothers had reduced albuminuria, N-acetyl-glucosaminidase, and urinary aldosterone excretion. These animals also did not show significant age-dependent renal telomere shortening and hence had significantly longer telomeres at 12 mo of age. This lack of renal telomere shortening was associated with increased levels of the antioxidant enzymes manganese superoxide dismutase, glutathione peroxidase, and glutathione reductase. These findings suggest that beneficial effects of slow growth during lactation are associated with increased antioxidant capacity and prevention of age-dependent telomere shortening in the kidney.

renal disease; albuminuria; telomeres; antioxidant enzymes

This article has been cited by other articles:

				M. S. Martin-Gronert, J. L. Tarry-Adkins, R. L. Cripps, J.-H. Chen, and S. E. Ozanne Maternal protein restriction leads to early life alterations in the expression of key molecules involved in the aging process in rat offspring Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R494 - R500. [Abstract] [Full Text] [PDF]

				M. F. Schreuder Combined nephroprotective effect and low nephron endowment as a consequence of postnatal growth restriction in the rat? Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R276 - R276. [Full Text] [PDF]

				J. A. Joles, J. L. Tarry-Adkins, S. Snoeijs, D. M. van der Giezen, R. Goldschmeding, and S. E. Ozanne Reply to: Schreuder Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R277 - R278. [Full Text] [PDF]