AJP - Regu Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 294: R673-R680, 2008. First published December 19, 2007; doi:10.1152/ajpregu.00561.2007
0363-6119/08 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
294/3/R673    most recent
00561.2007v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (21)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wei, Y.
Right arrow Articles by Sowers, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wei, Y.
Right arrow Articles by Sowers, J. R.

INVITED REVIEW

CALL FOR PAPERS
Insulin Resistance and Cardiometabolic Syndrome: Adipose Tissue and Skeletal Muscle Factors

Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species

Yongzhong Wei,1 Kemin Chen,1 Adam T. Whaley-Connell,1,3 Craig S. Stump,4 Jamal A. Ibdah,1,2,3 and James R. Sowers1,2,3

Departments of 1Internal Medicine, 2Physiology and Pharmacology, University of Missouri School of Medicine, Columbia, Missouri; 3Harry Truman VA Medical Center, Columbia, Missouri; and 4Department of Internal Medicine, University of Arizona, Tucson, Arizona

Submitted 3 August 2007 ; accepted in final form 4 December 2007

The cardiometabolic syndrome (CMS), with its increased risk for cardiovascular disease (CVD), nonalcoholic fatty liver disease (NAFLD), and chronic kidney disease (CKD), has become a growing worldwide health problem. Insulin resistance is a key factor for the development of the CMS and is strongly related to obesity, hyperlipidemia, hypertension, type 2 diabetes mellitus (T2DM), CKD, and NAFLD. Insulin resistance in skeletal muscle is particularly important since it is normally responsible for more than 75% of all insulin-mediated glucose disposal. However, the molecular mechanisms responsible for skeletal muscle insulin resistance remain poorly defined. Accumulating evidence indicates that low-grade chronic inflammation and oxidative stress play fundamental roles in the development of insulin resistance, and inflammatory cytokines likely contribute to the link between inflammation, oxidative stress, and skeletal muscle insulin resistance. Understanding the mechanisms by which skeletal muscle tissue develops resistance to insulin will provide attractive targets for interventions, which may ultimately curb this serious problem. This review is focused on the effects of inflammatory cytokines and oxidative stress on insulin signaling in skeletal muscle and consequent development of insulin resistance.


Address for reprint requests and other correspondence: J. R. Sowers, Univ. of Missouri-Columbia, Depts. of Internal Medicine, Medical Pharmacology and Physiology, The MU Diabetes and Cardiovascular Center, One Hospital Dr., Columbia, MO 65212 (e-mail: sowersj{at}health.missouri.edu)




This article has been cited by other articles:


Home page
 Exp PhysiolHome page
Y. Nagai, A. Ichihara, D. Nakano, S. Kimura, N. Pelisch, Y. Fujisawa, H. Hitomi, N. Hosomi, H. Kiyomoto, M. Kohno, et al.
Possible contribution of the non-proteolytic activation of prorenin to the development of insulin resistance in fructose-fed rats
Exp Physiol, September 1, 2009; 94(9): 1016 - 1023.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. F. Tong, X. Yan, M. J. Zhu, S. P. Ford, P. W. Nathanielsz, and M. Du
Maternal obesity downregulates myogenesis and {beta}-catenin signaling in fetal skeletal muscle
Am J Physiol Endocrinol Metab, April 1, 2009; 296(4): E917 - E924.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. Laczy, B. G. Hill, K. Wang, A. J. Paterson, C. R. White, D. Xing, Y.-F. Chen, V. Darley-Usmar, S. Oparil, and J. C. Chatham
Protein O-GlcNAcylation: a new signaling paradigm for the cardiovascular system
Am J Physiol Heart Circ Physiol, January 1, 2009; 296(1): H13 - H28.
[Abstract] [Full Text] [PDF]

Home page
 ptjournalHome page
T. N Hilton, L. J Tuttle, K. L Bohnert, M. J Mueller, and D. R Sinacore
Excessive Adipose Tissue Infiltration in Skeletal Muscle in Individuals With Obesity, Diabetes Mellitus, and Peripheral Neuropathy: Association With Performance and Function
Physical Therapy, November 1, 2008; 88(11): 1336 - 1344.
[Abstract] [Full Text] [PDF]

Home page
 ptjournalHome page
R. L Marcus, S. Smith, G. Morrell, O. Addison, L. E Dibble, D. Wahoff-Stice, and P. C LaStayo
Comparison of Combined Aerobic and High-Force Eccentric Resistance Exercise With Aerobic Exercise Only for People With Type 2 Diabetes Mellitus
Physical Therapy, November 1, 2008; 88(11): 1345 - 1354.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2008 by the American Physiological Society.