HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 295/1/R76    most recent 90327.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Bello, N. T. Articles by Moran, T. H. Search for Related Content PubMed PubMed Citation Articles by Bello, N. T. Articles by Moran, T. H.

APPETITE, OBESITY, AND DIGESTION

Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland

Submitted 31 March 2008 ; accepted in final form 13 May 2008

Amylinergic mechanisms are believed to be involved in the control of appetite. This study examined the effects of the amylin agonist, salmon calcitonin, on food intake and meal patterns in adult male rhesus monkeys. Fifteen minutes before the onset of their 6-h daily feeding period, monkeys received intramuscular injections of various doses of salmon calcitonin (0.032, 0.056, 0.1, 0.32, and 1 µg/kg) or saline. Salmon calcitonin dose dependently reduced total daily and hourly food intake, with significant decreases at the 0.1, 0.32, and 1 µg/kg doses. Daily food intake was reduced by 35%, 62%, and 96%, at these doses, respectively. An analysis of meal patterns revealed that size of the first meal was significantly reduced across the dose range of 0.056 to 1 µg/kg, while average meal size was reduced with the 0.32 and 1 µg/kg doses. Meal number was only affected at the 1 µg/kg dose. Repeated 5-day administration of the 0.1 µg/kg dose resulted in a reduction in daily food intake only on injection day 2, while significant reductions in food intake were observed on all five injection days with a 0.32 µg/kg dose. Daily food intake was also reduced for 1 day after the termination of the 5-day injections of the 0.32 µg/kg salmon calcitonin dose. These sustained reductions in intake were expressed through decreases in meal size. These data demonstrate that salmon calcitonin acutely and consistently decreases food intake mainly through reductions in meal sizes in nonhuman primates.

satiation; islet amyloid polypeptide; calcitonin-gene related peptides