HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 295/2/R528    most recent 90342.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shioura, K. M. Articles by Goldspink, P. H. Search for Related Content PubMed PubMed Citation Articles by Shioura, K. M. Articles by Goldspink, P. H.

HEMODYNAMICS AND CARDIORENAL INTEGRATION

Sex-related changes in cardiac function following myocardial infarction in mice

Department of Medicine, Section of Cardiology, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois

Submitted 3 April 2008 ; accepted in final form 7 June 2008

Recent awareness of cardiovascular diseases as a number one killer of the middle-aged women has prompted interest in sex differences leading to heart failure (HF). Therefore, we evaluated cardiac function in female and male mice following myocardial infarction (MI) using the Millar pressure-volume (P-V) conductance system in vivo, at time points corresponding to early (2 wk), late compensatory hypertrophy (4 wk), and decompensation (10 wk) to HF. A significant deterioration of the load dependent and independent hemodynamic measurements occurred in both female and male mice during the early phase of hypertrophy. Later, compensatory hypertrophy was marked by a normalization of volumes to control levels in females compared with males. The most notable differences between sexes occurred in the measurements of cardiac contractility during the decompensation to HF. In females, there was a significant improvement in contractility compared with males, which was apparent in the load-independent measurements of preload recruitable stroke work (10 wk post-MI, female = 48.7 ± 8.0 vs. male = 25.2 ± 1.8 mmHg, P < 0.05) and maximum dP/dt vs. maximum end-diastolic volume (10 wk post-MI, female=359 ± 58 vs. male=149 ± 28 mmHg·s^–1·µl^–1, P < 0.05). Despite these differences, there were no differences in the heart weight to body weight ratio and infarct size between the sexes. These data demonstrate that compensatory hypertrophy is associated with an improvement in contractility and a delayed decompensation to HF in females. However, compensatory hypertrophy in males appears to be undermined by a steady decline in contractility associated with decompensation to HF.

contractility; pressure-volume loops

This article has been cited by other articles:

				B. Ostadal, I. Netuka, J. Maly, J. Besik, and I. Ostadalova Gender Differences in Cardiac Ischemic Injury and Protection--Experimental Aspects Experimental Biology and Medicine, September 1, 2009; 234(9): 1011 - 1019. [Abstract] [Full Text] [PDF]