HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 295/2/R575    most recent 90354.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Szeto, I. M. Y. Articles by Anderson, G. H. Search for Related Content PubMed PubMed Citation Articles by Szeto, I. M. Y. Articles by Anderson, G. H.

DEVELOPMENTAL PHYSIOLOGY AND PREGNANCY

High multivitamin intake by Wistar rats during pregnancy results in increased food intake and components of the metabolic syndrome in male offspring

Departments of ¹Nutritional Sciences and ²Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, and ³Nutrition Research Division, Food Directorate, Health Canada, Ottawa, Ontario, Canada

Submitted 11 April 2008 ; accepted in final form 29 May 2008

The effect of high multivitamin intake during pregnancy on the metabolic phenotype of rat offspring was investigated. Pregnant Wistar rats (n = 10 per group) were fed the AIN-93G diet with the recommended vitamin (RV) content or a 10-fold increase [high vitamin (HV) content]. In experiment 1, male and female offspring were followed for 12 wk after weaning; in experiment 2, only males were followed for 28 wk. Body weight (BW) was measured weekly. Every 4 wk, after an overnight fast, food intake over 1 h was measured 30 min after a gavage of glucose or water. An oral glucose tolerance test was performed every 3–5 wk. Postweaning fasting glucose, insulin, ghrelin, glucagon-like peptide-1, and systolic blood pressure were measured. No difference in BW at birth or litter size was observed. Food intake was greater in males born to HV dams (P < 0.05), and at 28 wk after weaning, BW was 8% higher (P < 0.05) and fat pad mass was 27% higher (P < 0.05). Food intake reduction after the glucose preload was nearly twofold less in males born to HV dams at 12 wk after weaning (P < 0.05). Fasting glucose, insulin, and ghrelin were 11%, 62%, and 41% higher in males from HV dams at 14 wk after weaning (P < 0.05). Blood glucose response was 46% higher at 23 wk after weaning (P < 0.01), and systolic blood pressure was 16% higher at 28 wk after weaning (P < 0.05). In conclusion, high multivitamin intake during pregnancy programmed the male offspring for the development of the components of metabolic syndrome in adulthood, possibly by its effects on central mechanisms of food intake control.

fetal programming; obesity; insulin resistance; satiety hormones