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APPETITE, OBESITY, AND DIGESTION

Prolonged hyperphagia with high-fat feeding contributes to exacerbated weight gain in rats with adult-onset obesity

Departments of ¹Pharmacology and Therapeutics and ²Aging and Geriatrics, University of Florida College of Medicine, ³Department of Veterans Affairs Medical Center, ⁴Department of Statistics, University of Florida College of Liberal Arts and Sciences, and ⁵Department of Epidemiology and Biostatistics, University of Florida College of Public Health and Health Professions, Gainesville, Florida

Submitted 8 October 2007 ; accepted in final form 11 June 2008

Leptin-resistant rats, when given a high-fat (HF) diet, have a delayed normalization of caloric intake and greater weight gain than those on a chow diet. Because aged, obese rats are leptin resistant, these data predict that they will also have a delayed normalization of caloric intake and exacerbated weight gain when provided a HF diet. To investigate this hypothesis, along with the consequences of a HF diet on voluntary wheel running, we compared various ages of rats on a HF or chow diet. HF-fed young rats spontaneously divided into diet-induced obese and diet-resistant rats. However, all aged rats were susceptible to the weight-gaining effects of HF feeding. Rate of initial weight gain was proportional to age, and peak caloric intake on the HF diet and the days required to normalize caloric intake to basal levels increased with age. Responsiveness to peripheral leptin before HF feeding revealed a dose-response decrease in food intake and body weight in the young but no responses in the aged to even the highest dose, 0.5 mg/day. In addition, both age and HF feeding decreased the tendency for wheel running, suggesting the propensity for inactivity with age and HF feeding may contribute to age-related obesity and accelerate the rate of diet-induced obesity. These results demonstrate that aged rats are more susceptible to the detrimental effects of a HF diet.

leptin resistance; voluntary wheel running; diet-induced obese; peripheral leptin dose response

This article has been cited by other articles:

				P. J. Scarpace and Y. Zhang Leptin resistance: a prediposing factor for diet-induced obesity Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R493 - R500. [Abstract] [Full Text] [PDF]