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This Article Full Text Full Text (PDF) All Versions of this Article: 295/3/R954    most recent 90406.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Yoshiyama, M. Articles by Takeda, M. Search for Related Content PubMed PubMed Citation Articles by Yoshiyama, M. Articles by Takeda, M.

COMPARATIVE AND EVOLUTIONARY PHYSIOLOGY

Sex-related differences in activity of lower urinary tract in response to intravesical acid irritation in decerebrate unanesthetized mice

¹Department of Urology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Chuo, Yamanashi, and ²Yamanashi Rehabilitation Hospital, Fuefuki, Yamanashi, Japan

Submitted 6 May 2008 ; accepted in final form 21 July 2008

Sex-related differences in lower urinary tract (LUT) activity responding to intravesical infusion of diluted acetic acid (A/A, pH 3.0) were investigated during cystometrograms in decerebrate unanesthetized mice. A/A produced a decrease of intercontraction intervals in both female and male animals, and the extent of the decrease in male mice was much less than in female mice [19 ± 5% (P = 0.03) vs. 65 ± 5% (P = 0.03); n = 6 for each], exhibiting a marked difference between the two groups in response to acid irritation of the LUT (P = 0.002). A/A reduced maximal voiding pressure (MVP) (19 ± 4%, P = 0.03) but had no effect on pressure threshold for inducing voiding contraction (PT) (P = 0.56) in females, whereas A/A did not change MVP (P = 1.00) but increased PT (16 ± 4%, P = 0.03) in males. A/A decreased bladder compliances of female and male mice in a similar fashion (44 ± 10% vs. 24 ± 7%, P = 0.03 for each). In male mice, A/A produced persistent dribbling of fluid after voiding contraction phase, which was virtually not seen in females. The present study demonstrates the differences between female and male mice in response to noxious stimulation in the LUT: the female bladder is more sensitive to the acid irritation, while the male urethra is more irritable to the noxious stimulus. Identification of mechanisms underlying sex-specific characteristics might be helpful for elucidating pathogenesis of painful bladder syndrome.

afferent; bladder tonus; detrusor contractility; efferent; urethral resistance