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APPETITE, OBESITY, AND DIGESTION

Fluctuations in central and peripheral temperatures associated with feeding behavior in rats

Behavioral Neuroscience Branch, National Institute on Drug Abuse—Intramural Research Program, National Institutes of Health, Baltimore, Maryland

Submitted 29 July 2008 ; accepted in final form 10 September 2008

We examined the pattern of temperature fluctuations in the nucleus accumbens (NAcc), temporal muscle, and skin, along with locomotion in food-deprived and nondeprived rats following the presentation of an open or closed food container and during subsequent eating or food-seeking behavior without eating. Although rats in food-deprived, quiet resting conditions had more than twofold lower spontaneous locomotion and lower temperature values than in nondeprived conditions, after presentation of a container, they consistently displayed food-seeking behavior, showing much larger and longer temperature changes. When the container was open, rats rapidly retrieved food and consumed it. Food consumption was preceded and accompanied by gradual increases in brain and muscle temperatures (1.5°C) and a weaker, delayed increase in skin temperature (0.8°C). All temperatures began to rapidly fall immediately after eating was completed, but NAcc and muscle temperatures returned to baseline after 35 min. When the container was closed and rats were unable to obtain food, they continued food-seeking activity during the entire period of presentation. Similar to eating, this activity was preceded and accompanied by gradual temperature increases in the brain and muscle, which were somewhat smaller than those during eating (1.2°C), with no changes in skin temperature. In contrast to trials with eating, NAcc and muscle temperatures continued to increase for 10 min after the container was removed from the cage and the rat continued food-seeking behavior, with a return to baselines after 50 min. These temperature fluctuations are discussed with respect to alterations in metabolic brain activity associated with feeding behavior, depending upon deprivation state and food availability.

eating; food seeking; deprivation; motivation; metabolic brain activation; peripheral vasoconstriction