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Am J Physiol Regul Integr Comp Physiol 296: R257-R264, 2009. First published November 12, 2008; doi:10.1152/ajpregu.90696.2008
0363-6119/09 $8.00
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HEMODYNAMICS AND CARDIORENAL INTEGRATION

Natriuretic peptides in hormonal regulation of hypoxia responses

Olli Arjamaa and Mikko Nikinmaa

Centre of Excellence in Evolutionary Genetics and Physiology, Department of Biology, University of Turku, Turku, Finland

Submitted 23 August 2008 ; accepted in final form 6 November 2008

The possibility that natriuretic peptides' effects are important in hypoxia responses of vertebrates is reviewed. Both the transcription and release of natriuretic peptides are affected by oxygen tension. Furthermore, many of the effects observed in hypoxia, such as diuresis and a reduction of plasma volume, are also caused by treatment of the animal with natriuretic peptides. Also, several clinical observations about changes in natriuretic peptide levels in, e.g., sleep apnea and cyanotic congenital heart disease, are consistent with the idea that hypoxia is involved in the etiology of conditions, in which natriuretic peptide levels increase. Virtually all published information on the relationship between oxygen and natriuretic peptides is based on human studies. Because hypoxic conditions are more common in aquatic than terrestrial environments, future studies about the possible role of natriuretic peptides in hypoxia, as well as the role of hypoxia in the evolution of natriuretic peptides, including the different subtypes, should increasingly involve also aquatic organisms.

low oxygen tension; cardiac hormones; mammals; fishes


Address for reprint requests and other correspondence: M. Nikinmaa, Centre of Excellence in Evolutionary Genetics and Physiology, Dept. of Biology, Univ. of Turku, FI-20014 Turku, Finland (e-mail: mikko.nikinmaa{at}utu.fi)






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