HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 296/2/R419    most recent 90784.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rieg, T. Articles by Vallon, V. Search for Related Content PubMed PubMed Citation Articles by Rieg, T. Articles by Vallon, V.

WATER AND ELECTROLYTE HOMEOSTASIS

ATP and adenosine in the local regulation of water transport and homeostasis by the kidney

¹Department of Medicine, Division of Nephrology and Hypertension, University of California San Diego; ²VA San Diego Healthcare System; and ³Department of Pharmacology, University of California San Diego, La Jolla, California

Submitted 22 September 2008 ; accepted in final form 13 November 2008

Regulation of body water homeostasis is critically dependent on the kidney and under the control of AVP, which is released from the neurohypophysis. In the collecting duct (CD) of the kidney, AVP activates adenylyl cyclase via vasopressin V₂ receptors. cAMP-dependent activation of protein kinase A phosphorylates the water channel aquaporin-2 and increases water permeability by insertion of aquaporin-2 into the apical cell membrane. However, local factors modulate the effects of AVP to fine tune its effects, accelerate responses, and potentially protect the integrity of CD cells. Nucleotides like ATP belong to these local factors and act in an autocrine and paracrine way to activate P2Y₂ receptors on CD cells. Extracellular breakdown of ATP and cAMP forms adenosine, the latter also induces specific effects on the CD by activation of adenosine A₁ receptors. Activation of both receptor types can inhibit the cAMP-triggered activation of protein kinase A and reduce water permeability and transport. This review focuses on the role and potential interactions of the ATP and adenosine system with regard to the regulation of water transport in the CD. We address the potential stimuli and mechanisms involved in nucleotide release and adenosine formation, and discuss the corresponding signaling cascades that are activated. Potential interactions between the ATP and adenosine system, as well as other factors involved in the regulation of CD function, are outlined. Data from pharmacological studies and gene-targeted mouse models are presented to demonstrate the in vivo relevance to water transport and homeostasis.

aquaporin-2; cAMP; collecting duct; vasopressin; cell volume

This article has been cited by other articles:

				E. Odgaard, H. A. Praetorius, and J. Leipziger AVP-stimulated nucleotide secretion in perfused mouse medullary thick ascending limb and cortical collecting duct Am J Physiol Renal Physiol, August 1, 2009; 297(2): F341 - F349. [Abstract] [Full Text] [PDF]