AJP - Regu AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 296: R1180-R1189, 2009. First published January 21, 2009; doi:10.1152/ajpregu.90813.2008
0363-6119/09 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
296/4/R1180    most recent
90813.2008v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Byerly, M. S.
Right arrow Articles by Porter, T. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Byerly, M. S.
Right arrow Articles by Porter, T. E.

COMPARATIVE AND EVOLUTIONARY PHYSIOLOGY

Effects of BDNF, T3, and corticosterone on expression of the hypothalamic obesity gene network in vivo and in vitro

Mardi S. Byerly,1,2 Jean Simon,3 Elisabeth Lebihan-Duval,3 Michel J. Duclos,3 Larry A. Cogburn,4 and Tom E. Porter1,2

1Neuroscience and Cognitive Science Program and 2Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland; 3Station de Recherches Avicoles, Institut National de la Recherche Agronomique, Centre de Recherches de Tours, Nouzilly, France; and 4Department of Animal and Food Sciences, University of Delaware, Newark, Delaware

Submitted 5 October 2008 ; accepted in final form 14 January 2009

Hypothalamic neuropeptides, neurotrophins, and systemic hormones modulate food intake and body composition. Although advances toward elucidating these interactions have been made, many aspects of the underlying mechanisms remain vague. Hypothalami from fat and lean chicken lines were assessed for differential expression of anabolic/orexigenic and catabolic/anorexigenic genes. Effects of triiodothyronine (T3), corticosterone (Cort), and brain-derived neurotrophic factor (BDNF) on expression of anabolic/orexigenic and catabolic/anorexigenic genes were tested in cultures of hypothalamic neurons. From this, we found that BDNF increased and T3 decreased gene expression for BDNF, leptin receptor (LEPR), pro-opiomelanocortin (POMC), thyrotropin releasing hormone (TRH), and agouti-related protein (AGRP). Thyroid hormone levels were manipulated during development to show that T3 inhibited BDNF, TRH, and BDNF receptor gene expression. Delivery of T3, Cort, T3 plus Cort, or vehicle in vivo continuously for 72 h indicated that Cort and T3 have overlapping roles in regulating TRH, LEPR, and POMC gene expression and that Cort and T3 regulate BDNF, neuropeptide Y, and AGRP in opposite directions. Collectively, these findings suggest that interactions between the neuropeptide BDNF and the hormones T3 and/or Cort may constitute a homeostatic mechanism that links hypothalamic energy regulation controlling body composition.

anabolic/orexigenic; orexigenic; catabolic/anorexigenic; anorexigenic; obesity; glucocorticoids; thyroid hormone; fat and lean lines; brain-derived neurotrophic factor; triiodothyronine


Address for reprint requests and other correspondence: T. E. Porter, Dept. of Animal and Avian Sciences, Univ. of Maryland, College Park, MD 20712 (e-mail: TEPorter{at}umd.edu)






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2009 by the American Physiological Society.