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Am J Physiol Regul Integr Comp Physiol 297: R111-R115, 2009. First published April 29, 2009; doi:10.1152/ajpregu.90588.2008
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ARTICLES

Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats

Katsunori Isa, Maria Antonia García-Espinosa, Amy C. Arnold, Nancy T. Pirro, Ellen N. Tommasi, Detlev Ganten, Mark C. Chappell, Carlos M. Ferrario, and Debra I. Diz

Hypertension and Vascular Research Center, Wake Forest University Health Science, Winston-Salem, North Carolina

Submitted 10 July 2008 ; accepted in final form 24 April 2009

Angiotensin-(1-12) [ANG-(1-12)] is a newly identified peptide detected in a variety of rat tissues, including the brain. To determine whether brain ANG-(1-12) participates in blood pressure regulation, we treated male adult (mRen2)27 hypertensive rats (24–28 wk of age) with Anti-ANG-(1-12) IgG or Preimmune IgG via an intracerebroventricular cannula for 14 days. Immunoneutralization of brain ANG-(1-12) lowered systolic blood pressure (–43 ± 8 mmHg on day 3 and –26 ± 7 mmHg on day 10 from baseline, P < 0.05). Water intake was lower on intracereroventricular day 6 in the Anti-ANG-(1-12) IgG group, accompanied by higher plasma osmolality on day 13, but there were no differences in urine volume, food intake, or body weight during the 2-wk treatment. In Preimmune IgG-treated animals, there were no significant changes in these variables over the 2-wk period. The antihypertensive effects produced by endogenous neutralization of brain ANG-(1-12) suggest that ANG-(1-12) is functionally active in brain pathways regulating blood pressure.

hypertension; transgenic rats; renin-angiotensin system; brain; sympathetic nerve; antibody


Address for reprint requests and other correspondence: D. I. Diz, The Hypertension & Vascular Research Center, Wake Forest Univ. School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157-1032 (e-mail: ddiz{at}wfubmc.edu)






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