HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 297/3/R813    most recent 00201.2009v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (1) Google Scholar Articles by Coupé, B. Articles by Parnet, P. PubMed PubMed Citation Articles by Coupé, B. Articles by Parnet, P.

ARTICLES

The timing of "catch-up growth" affects metabolism and appetite regulation in male rats born with intrauterine growth restriction

¹Institut National de la Recherche Agronomique, UMR 1280 Physiologie des Adaptations Nutritionnelles, Université de Nantes, Nantes, France; and ²Institut des Maladies de l'Appareil Digestif, Centre Hospital-Universitaire de Nantes, Nantes, France

Submitted 8 April 2009 ; accepted in final form 8 July 2009

Epidemiological studies demonstrated a relationship between low birth weight mainly caused by intrauterine growth restriction (IUGR) and adult metabolic disorders. The concept of metabolic programming centers on the idea that nutritional and hormonal status during the key period of development determines the long-term control of energy balance by programming future feeding behavior and energy expenditure. The present study examined the consequence of early or late "catch-up growth" after IUGR on feeding behavior and metabolic cues of male offspring of rat dams exposed to protein restriction during gestation and/or lactation. Our results suggest that early catch-up growth may be favorable for fasting metabolic parameters at weaning, as no differences were observed on plasma leptin, triglyceride, glucose, and insulin levels compared with controls. In contrast, if pups remained malnourished until weaning, low insulin concentration was detected and was accompanied by hyperphagia associated with a large increase in hypothalamic NPY and AgRP mRNA expression. At adult age, on a regular chow diet, only the meal structure was modified by fetal programming. The two IUGR groups demonstrated a reduced meal duration that enhanced the speed of food ingestion and consequently increased the rest period associated to the satiety state without changes in the hypothalamic expression of appetite neuropeptides. Our findings demonstrate that in IUGR, regardless of postnatal growth magnitude, metabolic programming occurred in utero and was responsible for both feeding behavior alteration and postprandial higher insulin level in adults. Additionally, catch-up growth immediately after early malnutrition could be a key point for the programming of postprandial hyperleptinemia.

perinatal nutrition; appetite neuropeptides; hypothalamus; feeding behavior

This article has been cited by other articles:

				S. D. Hursting and M. R. Forman Cancer Risk From Extreme Stressors: Lessons From European Jewish Survivors of World War II J Natl Cancer Inst, November 4, 2009; 101(21): 1436 - 1437. [Full Text] [PDF]