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1 Health and Kinesiology, Texas A&M University, College Station, Texas, USA
2 Physical Therapy, Georgia State University, Atlanta, Georgia, USA
* To whom correspondence should be addressed. E-mail: rb-armstrong{at}hlkn.tamu.edu.
The purpose of this study was to determine if the elimination of satellite cell proliferation using 
-irradiation would inhibit normal force recovery following eccentric contraction-induced muscle injury. Adult female ICR mice were implanted with a stimulating nerve cuff on the common peroneal nerve and assigned to 1 of 4 groups: 1) irradiation and eccentric contraction-induced injury, 2) eccentric contraction-induced injury only, 3) irradiation only, and 4) no intervention. Anterior crural muscles were irradiated with a dose of 2500 rads and injured with 150 in vivo maximal eccentric contractions. Maximal isometric torque was determined weekly through 35 d post-injury. Immediately following injury, maximal isometric torque was reduced by ~50% and had returned to normal by 28 d post-injury in the non-irradiated injured mice. However, torque production of irradiated injured animals did not recover fully, and was 25% less than that of injured non-irradiated mice 35 d post-injury. These data suggest that satellite cell proliferation is required for approximately half of the force recovery following eccentric contraction-induced injury.
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