AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (August 14, 2003). doi:10.1152/ajpregu.00032.2003
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/6/R1490    most recent
00032.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rathbone, C. R
Right arrow Articles by Armstrong, R B
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rathbone, C. R
Right arrow Articles by Armstrong, R B
Submitted on January 22, 2003
Accepted on August 1, 2003

Importance of Satellite Cells in the Strength Recovery after Eccentric Contraction-Induced Muscle Injury

Christopher R Rathbone1, J C Wenke1, Gordon L Warren2, and R B Armstrong1*

1 Health and Kinesiology, Texas A&M University, College Station, Texas, USA
2 Physical Therapy, Georgia State University, Atlanta, Georgia, USA

* To whom correspondence should be addressed. E-mail: rb-armstrong{at}hlkn.tamu.edu.

The purpose of this study was to determine if the elimination of satellite cell proliferation using {gamma}-irradiation would inhibit normal force recovery following eccentric contraction-induced muscle injury. Adult female ICR mice were implanted with a stimulating nerve cuff on the common peroneal nerve and assigned to 1 of 4 groups: 1) irradiation and eccentric contraction-induced injury, 2) eccentric contraction-induced injury only, 3) irradiation only, and 4) no intervention. Anterior crural muscles were irradiated with a dose of 2500 rads and injured with 150 in vivo maximal eccentric contractions. Maximal isometric torque was determined weekly through 35 d post-injury. Immediately following injury, maximal isometric torque was reduced by ~50% and had returned to normal by 28 d post-injury in the non-irradiated injured mice. However, torque production of irradiated injured animals did not recover fully, and was 25% less than that of injured non-irradiated mice 35 d post-injury. These data suggest that satellite cell proliferation is required for approximately half of the force recovery following eccentric contraction-induced injury.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
B. T. Corona, C. Rouviere, S. L. Hamilton, and C. P. Ingalls
FKBP12 deficiency reduces strength deficits after eccentric contraction-induced muscle injury
J Appl Physiol, August 1, 2008; 105(2): 527 - 537.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. J. Hubal, T. C. Chen, P. D. Thompson, and P. M. Clarkson
Inflammatory gene changes associated with the repeated-bout effect
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1628 - R1637.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. L. Warren, M. Summan, X. Gao, R. Chapman, T. Hulderman, and P. P. Simeonova
Mechanisms of skeletal muscle injury and repair revealed by gene expression studies in mouse models
J. Physiol., July 15, 2007; 582(2): 825 - 841.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Scholz
Unraveling the basic principles
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1485 - R1487.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. C. Gallegly, N. A. Turesky, B. A. Strotman, C. M. Gurley, C. A. Peterson, and E. E. Dupont-Versteegden
Satellite cell regulation of muscle mass is altered at old age
J Appl Physiol, September 1, 2004; 97(3): 1082 - 1090.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
G. L. Warren, L. O'Farrell, M. Summan, T. Hulderman, D. Mishra, M. I. Luster, W. A. Kuziel, and P. P. Simeonova
Role of CC chemokines in skeletal muscle functional restoration after injury
Am J Physiol Cell Physiol, May 1, 2004; 286(5): C1031 - C1036.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.