AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (March 29, 2002). doi:10.1152/ajpregu.00033.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/2/R505    most recent
00033.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zimmerman, M. A
Right arrow Articles by Harken, A. H
Right arrow Search for Related Content
PubMed
Right arrow Articles by Zimmerman, M. A
Right arrow Articles by Harken, A. H

Articles in PresS, published online ahead of print March 28, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00033.2002
Submitted on January 22, 2002
Accepted on March 25, 2002

Lack of TNF{alpha} attenuates intimal hyperplasia following mouse carotid injury

Michael A Zimmerman1, Craig H Selzman1*, Leonid L Reznikov1, Stephanie A Miller1, Christopher D Raeburn1, Julie Emmick2, Xianzhong Meng1, and Alden H Harken1

1 Department of Surgery, University of Colorado Health Sciences Center, Denver, CO, USA
2 Source Precision Medicine, Boulder, CO, USA

* To whom correspondence should be addressed. E-mail: michael.zimmerman{at}uchsc.edu.

This study sought to determine the obligate influence of tumor necrosis factor alpha (TNF{alpha}) on intimal hyperplasia (IH) and characterize the mechanisms of transcriptional regulation following vascular injury. A murine model of wire carotid arterial injury was employed to induce IH in wild type (WT) and TNF{alpha}-deficient (TNF-/-) animals. Three days after injury, TNF{alpha} and NF{kappa}B protein expression was markedly increased in the injured WT carotid artery compared to control. Injury increased TNF{alpha} and NF{kappa}B mRNA expression 100-fold and 7.5-fold respectively. Compared to WT specimens, injury in TNF -/- animals decreased both NF{kappa}B mRNA and protein nearly 7.5-fold and 4-fold, respectively. Expression of the NF{kappa}B-dependent cytokine monocyte chemotactic protein-1 was markedly diminished in injured TNF -/- animals. Finally, TNF -/- animals demonstrated a 7-fold reduction in IH compared to WT animals. Cumulatively, these data mechanistically link {alpha}TNF and NF{kappa}B and suggest an important influence of TNFa on post-injury IH.




This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
H. Murayama, M. Takahashi, M. Takamoto, Y. Shiba, H. Ise, J. Koyama, Y.-i. Tagawa, Y. Iwakura, and U. Ikeda
Deficiency of tumour necrosis factor-{alpha} and interferon-{gamma} in bone marrow cells synergistically inhibits neointimal formation following vascular injury
Cardiovasc Res, November 1, 2008; 80(2): 175 - 180.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
K. Peppel, L. Zhang, E. S. Orman, P.-O. Hagen, A. Amalfitano, L. Brian, and N. J. Freedman
Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms
Cardiovasc Res, February 15, 2005; 65(3): 674 - 682.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
L. Zhang, K. Peppel, L. Brian, L. Chien, and N. J. Freedman
Vein Graft Neointimal Hyperplasia Is Exacerbated by Tumor Necrosis Factor Receptor-1 Signaling in Graft-Intrinsic Cells
Arterioscler. Thromb. Vasc. Biol., December 1, 2004; 24(12): 2277 - 2283.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. A. Zimmerman, L. L. Reznikov, A. C. Sorensen, and C. H. Selzman
Relative contribution of the TNF-alpha receptors to murine intimal hyperplasia
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1213 - R1218.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Ehmke
Mouse gene targeting in cardiovascular physiology
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R28 - R30.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2002 by the American Physiological Society.