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Am J Physiol Regul Integr Comp Physiol (December 15, 2005). doi:10.1152/ajpregu.00075.2003
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Submitted on February 7, 2003
Accepted on December 8, 2005

CORTICOTROPIN-RELEASING HORMONE IN THE LATERAL PARABRACHIAL NUCLEUS INHIBITS SODIUM APPETITE IN RATS

Emilio De Castro E Silva1, Josmara B Fregoneze1, and Alan Kim Johnson2*

1 Physiology, Federal University of Bahia, Health Sciences Institute, Salvador, Bahia, Brazil
2 Psychology, Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa, USA

* To whom correspondence should be addressed. E-mail: alan-johnson{at}uiowa.edu.

The present study investigated the role of corticotropin-releasing hormone (CRH) in the lateral parabrachial nucleus (LPBN) in the behavioral control of body fluid homeostasis by determining the effect of bilateral injections of the CRH receptor antagonist, {alpha}-helical CRF9-41, and the CRH receptor agonist, CRH, on sodium chloride (salt appetite) and water (thirst) intake. Groups of adult, male Sprague-Dawley rats had stainless steel cannulas implanted bilaterally into the LPBN and were sodium depleted or water deprived. Bilateral injections of {alpha}-helical CRF9-41 into the LPBN significantly potentiated water and salt intake in the sodium depleted rats when access to fluids was restored. Bilateral injections of {alpha}-helical CRF9-41 into the LPBN (1.0 µg) also increased sodium appetite in water deprived rats. Conversely, in sodium depleted animals, bilateral injections of CRH inhibited sodium chloride intake. These results suggest that there is an endogenous CRH inhibitory mechanism operating in the LPBN to modulate the intake of sodium (salt appetite). This mechanism may contribute to the behavioral control of restoration of body fluid homeostasis in sodium deficient states.




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