Submitted on February 6, 2008
Revised on April 9, 2009
Accepted on April 9, 2009
Role of cardiopulmonary and carotid sinus baroreceptors in regulating renal sympathetic nerve activity during water immersion in conscious dogs
Kenju Miki1*, Misa Yoshimoto1, Yoshiaki Hayashida, and Keizo Shiraki2
1 Nara Women's University
2 Univ. of Occupational + Environmental Health
* To whom correspondence should be addressed. E-mail: k.miki{at}cc.nara-wu.ac.jp.
The present study aimed to investigate how loading of cardiopulmonary baroreceptors induced by water immersion (WI) modifies baroreflex control of renal sympathetic nerve activity (RSNA) in conscious dogs. Nine dogs were chronically instrumented for measuring carotid sinus nerve activity (CSNA), renal sympathetic nerve activity (RSNA), carotid arterial (Pca) and central venous (Pcv) pressures. The stimulus-response relationships of Pca-CSNA and Pca-RSNA were determined simultaneously in the same dog by changing Pca using rapid intravenous infusions vasoactive drugs during pre-WI and WI. WI increased central venous pressure significantly (P<0.05) by 10.4 mmHg. WI shifted the Pca-RSNA curve acutely to leftward compared with the pre-WI period, which was associated with significant (P<0.05) decreases in the saturation pressure by 39.0 mmHg and operating range by 43.1 mmHg. WI relocated the operating pressure to near the saturation pressure where the gain was low. The Pca-CSNA curve obtained during WI was identical to that obtained during pre-WI period. These results suggest that the shift in baroreflex control of RSNA could be attributed to the inhibitory influence of the cardiopulmonary mechanoreceptor loading and not by the resetting of carotid baroreceptors per se.
