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1 CNRS, LYON, France; Physiology, University Lyon 1, LYON, France
2 Physiology, University Lyon 1, LYON, France
* To whom correspondence should be addressed. E-mail: julien{at}univ-lyon1.fr.
The role of arterial baroreceptors in controlling arterial pressure (AP) variability through changes in sympathetic nerve activity (SNA) was examined in conscious rats. AP and renal SNA (RSNA) were measured continuously during 1-h periods in freely behaving rats that had been submitted either to sinoaortic baroreceptor denervation (SAD) or to a sham operation 2 weeks before study (n = 10 in each group). Fast Fourier transform analysis revealed that chronic SAD did not alter high-frequency (0.75-5 Hz) respiratory-related oscillations of mean AP (MAP) and RSNA, decreased by ~50% spectral power of both variables in the mid-frequency band (MF, 0.27-0.74 Hz) containing the so-called Mayer waves, and induced an 8-fold increase in MAP power without altering RSNA power in the low-frequency band (0.005-0.27 Hz). In both groups of rats, coherence between RSNA and MAP was maximum in the MF band and was usually weak at lower frequencies. In SAD rats, the transfer function from RSNA to MAP showed the characteristics of a second-order low-pass filter containing a fixed time delay (~0.5 s). These results indicate that arterial baroreceptors are not involved in the production of respiratory-related oscillations of RSNA, but play a major role in the genesis of synchronous oscillations of MAP and RSNA at the frequency of Mayer waves. The weak coupling between slow fluctuations of RSNA and MAP in both sham-operated and SAD rats points to the interference of noise sources unrelated to RSNA affecting MAP, and of noise sources unrelated to MAP affecting RSNA.
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