| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Neuroendocrinologie Moleculaire de la prise alimentaire, UNiversity Paris 11, ORSAY, France
2 Neuroendocrinologie Moleculaire de la prise alimentaire, UNiversity Paris 11, ORSAY, France; Neuroedocrinologie Moleculaire de la prise alimentaire, UNiversity Paris 11, ORSAY, France
3 Neuroedocrinologie Moleculaire de la prise alimentaire, UNiversity Paris 11, ORSAY, France; Neuroendocrinologie Moleculaire de la prise alimentaire, UNiversity Paris 11, ORSAY, France
4 Agriculture, The Hebrew University of Jerusalem, Rehovot, Israel
* To whom correspondence should be addressed. E-mail: jacqueline.ferezou{at}u-psud.fr.
Epidemiological studies suggest that the alteration of hormonal and metabolic environment during fetal and neonatal development contributes to development of metabolic syndrome in adulthood. Here, we investigate the impact of maternal high-fat (HF) diet on hypothalamic leptin sensitivity and body weight gain of offspring. Adult Wistar female rats received HF or control diet (C) diet for 6 weeks before gestation until the end of the suckling period. After weaning, pups received either C or HF diet during 6 weeks. Body weight gain, metabolic and endocrine parameters were measured in the 8 groups of rats formed according to post-weaning diet, maternal diet and gender. To evaluate hypothalamic leptin sensitivity in each group, STAT-3 phosphorylation was measured in response to leptin intraperitoneal bolus. Pups exhibited similar body weights at birth but at weaning, those born to HF dams weighed significantly less (-12%) than those born to C dams. Under HF diet, males and females born to HF dams exhibited smaller body weight and feed efficiency than those born to C dams, suggesting increased energy expenditure programmed by the maternal HF diet. Thus, maternal HF feeding could be protective against adverse effects of the HF diet as observed in male offspring of control dams: overweight (+17%) with hyperleptinemia and hyperinsulinemia. Furthermore, offspring of HF dams fed either C or HF diet exhibited an alteration in hypothalamic leptin-dependent STAT-3 phosphorylation. We conclude that maternal high-fat diet programs a hypothalamic leptin resistance in offspring which, however, fails to increase the body weight gain until adulthood.
This article has been cited by other articles:
|
|
 |
|
  M. M. McCarthy, A. P. Auger, T. L. Bale, G. J. De Vries, G. A. Dunn, N. G. Forger, E. K. Murray, B. M. Nugent, J. M. Schwarz, and M. E. Wilson The Epigenetics of Sex Differences in the Brain J. Neurosci., October 14, 2009; 29(41): 12815 - 12823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Page, R. E. Malik, J. A. Ripple, and E. K. Anday Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2009; 297(4): R1049 - R1057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Shelley, M. S. Martin-Gronert, A. Rowlerson, L. Poston, S. J. R. Heales, I. P. Hargreaves, J. M. McConnell, S. E. Ozanne, and D. S. Fernandez-Twinn Altered skeletal muscle insulin signaling and mitochondrial complex II-III linked activity in adult offspring of obese mice Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2009; 297(3): R675 - R681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Chechi, J. J. McGuire, and S. K. Cheema Developmental programming of lipid metabolism and aortic vascular function in C57BL/6 mice: a novel study suggesting an involvement of LDL-receptor Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1029 - R1040. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. S. Bhasin, A. van Nas, L. J. Martin, R. C. Davis, S. U. Devaskar, and A. J. Lusis Maternal Low-Protein Diet or Hypercholesterolemia Reduces Circulating Essential Amino Acids and Leads to Intrauterine Growth Restriction Diabetes, March 1, 2009; 58(3): 559 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Howie, D. M. Sloboda, T. Kamal, and M. H. Vickers Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet J. Physiol., February 15, 2009; 587(4): 905 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mitra, K. M. Alvers, E. M. Crump, and N. E. Rowland Effect of high-fat diet during gestation, lactation, or postweaning on physiological and behavioral indexes in borderline hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2009; 296(1): R20 - R28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-Q. Chang, V. Gaysinskaya, O. Karatayev, and S. F. Leibowitz Maternal High-Fat Diet and Fetal Programming: Increased Proliferation of Hypothalamic Peptide-Producing Neurons That Increase Risk for Overeating and Obesity J. Neurosci., November 12, 2008; 28(46): 12107 - 12119. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
