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Articles in PresS, published online ahead of print May 6, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00120.2002
Submitted on February 22, 2002
Accepted on May 3, 2002
1 Department of Exercise and Sport Science, Oregon State University, Corvallis, OR, USA
* To whom correspondence should be addressed. E-mail: jeff.widrick{at}orst.edu.
The aim of this study was to assess the relationships between human muscle fiber hypertrophy, protein isoform content, and maximal Ca2+-activated contractile function following a short-term period of resistance exercise training. Six male subjects (age 27 ± 2 yrs) participated in a 12 week progressive resistance exercise training program that increased voluntary lower limb extension strength by > 60%. Single chemically skinned fibers were prepared from pre- and post-training vastus lateralis muscle biopsies. Training increased the CSA and peak Ca2+-activated force (Po) of fibers containing type I, IIa, or IIa/IIx myosin heavy chain by 30-40% without affecting fiber specific force (Po/CSA) or unloaded shortening velocity (Vo). Absolute fiber peak power rose as a result of the increase in Po while power normalized to fiber volume was unchanged. At the level of the cross-bridge, the effects of short-term resistance training were quantitative (fiber hypertrophy and proportional increases in fiber Po and absolute power) rather than qualitative (no change in Po/CSA, Vo, or power/fiber volume).
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