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Am J Physiol Regul Integr Comp Physiol (April 24, 2003). doi:10.1152/ajpregu.00130.2003
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Submitted on March 10, 2003
Accepted on April 21, 2003

Investigations on the Physiological Controls of Water and Saline Intake in C57BL/6 Mice

Ralph F Johnson1, Terry G Beltz1, Robert L Thunhorst1, and Alan K Johnson2*

1 Department of Psychology, University of Iowa, Iowa City, IA, USA
2 Department of Psychology, University of Iowa, Iowa City, IA, USA; Pharmacology & the Cardiovascular Center, University of Iowa, Iowa City, IA, USA

* To whom correspondence should be addressed. E-mail: alan-johnson{at}uiowa.edu.

To examine the behavioral and neural control of body fluid homeostasis, water and saline intake of C57BL/6 mice was monitored ad libitum, after dipsogenic treatments or treatments that induce salt intake, and after ablation of the periventricular tissue of the anteroventral third ventricle (AV3V). Mice have nocturnal drinking that is most prevalent after the offset and before the onset of lights. When given ad libitum choice, C57BL/6 mice show no preference for saline over water at concentrations up to 0.9% NaCl and a progressive aversion to saline above that concentration. Systemic hypertonic saline, isoproterenol and polyethylene glycol treatments are dipsogenic, however, systemic angiotensin II (ANG II) is not. Both intracerebroventricular injections of hypertonic saline and of ANG II are dipsogenic, and diuretic treatment followed by a short period of sodium deprivation induces salt intake. After ablation of the AV3V, mice can be nursed to recovery from initial adipsia and like rats, show chronic deficits to dipsogenic treatments. Taken together, the data indicate that mechanisms controlling thirst in response to cellular dehydration in C57BL/6 mice are similar to rats, but that there are differences in the efficacy of extracellular dehydration-related mechanisms, especially for systemic ANG II, controlling thirst and salt appetite.




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