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1 Department of Pediatrics, Kosair Children's Hospital Research Institute, Louisville, KY, USA; Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, KY, USA
2 Department of Pediatrics, Kosair Children's Hospital Research Institute, Louisville, KY, USA
3 Department of Physiology, Loyola University Chicago, Maywood, IL, USA
4 Department of Pediatrics, Kosair Children's Hospital Research Institute, Louisville, KY, USA; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA
* To whom correspondence should be addressed. E-mail: zjchen01{at}gwsie.louisville.edu.
In previous single-labeling experiments, we showed that neurons in the nucleus ambiguus (NA) and the dorsal motor nucleus of the vagus (DmnX) project to intrinsic cardiac ganglia. Neurons in these two motor nuclei differ significantly in the size of their projection fields, axon caliber, and endings in cardiac ganglia. These differences in NA and DmnX axon cardiac projections raise the question as to whether they target the same, distinct, or overlapping populations of cardiac principal neurons. To address this issue, we examined vagal terminals in cardiac ganglia and tracer injection sites in the brainstem using two different anterograde tracers (DiI and DiA) and confocal microscopy in male Sprague Dawley rats. We found that (i) NA and DmnX neurons innervate the same cardiac ganglia, but these axons target separate subpopulations of principal neurons; (ii) axons arising from neurons in the NA and DmnX in the contralateral sides of the brainstem enter cardiac the ganglionic plexus through separate bundles and preferentially innervate principal neurons near their entry regions, providing topographic mapping of vagal motor neurons in left and right brainstem vagal nuclei. Since the NA and DmnX project to distinct populations of cardiac principal neurons, we propose that they may play different roles in controlling cardiac function.
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