| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Laboratoire de Neuroendocrinologie des Insectes, Universite Bordeaux I, Talence, Cedex, France; Plasticite du systeme Nerveux, CNRS, Developpement, Evolution, Gif-sur-Yvette, France
2 Bases Neurales du Mouvement chez la Drosophile, laboratoire de neurobiologie de l'apprentissage, de la memoire, et de la communication, CNRS/Universite Paris sud, Orsay, France
3 Laboratoire de Neuroendocrinologie des Insectes, Universite Bordeaux I, Talence, Cedex, France
4 Laboratoire de Neuroendocrinologie des Insectes, Universite Bordeaux I, Talence, Cedex, France; Laboratoire des Neurosciences Cognitives, CNRS/Universite Bordeaux, Talence, Cedex, France
* To whom correspondence should be addressed. E-mail: p.rosay{at}lnc.u-bordeaux1.fr.
Adipokinetic hormone (AKH) is a metabolic neuropeptide principally known for its mobilization of energy substrates, notably lipid and trehalose during energy-requiring activities, such as flight and locomotion. Drosophila melanogaster AKH cells localization in corpora cardiaca, as in other insects species, was confirmed by immunoreactivity and by a genetic approach using UAS/GAL4 system. To assess AKH general physiological rules, we ablated AKH endocrine cells by specifically driving the expression of apoptosis transgenes in AKH cells. Trehalose levels were decreased in larvae and starved adults, when the stimulation by AKH of the production of trehalose from fat body glycogen is no longer possible. Moreover, we show that these adults without AKH-cells become progressively hypoactive. Finally, under starvation conditions, those hypoactive AKH-knockout cells flies survived about 50% longer than control wild-type flies, suggesting that the slower rate at which AKH-ablated flies mobilize their energy resources, extends their survival.
This article has been cited by other articles:
|
|
 |
|
  M. Shahidullah, S. Reddy, H. Fei, and I. B. Levitan In Vivo Role of a Potassium Channel-Binding Protein in Regulating Neuronal Excitability and Behavior J. Neurosci., October 21, 2009; 29(42): 13328 - 13337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Lorenz and G. Gade Hormonal regulation of energy metabolism in insects as a driving force for performance Integr. Comp. Biol., October 1, 2009; 49(4): 380 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Pruijssers, P. Falabella, J. H. Eum, F. Pennacchio, M. R. Brown, and M. R. Strand Infection by a symbiotic polydnavirus induces wasting and inhibits metamorphosis of the moth Pseudoplusia includens J. Exp. Biol., September 15, 2009; 212(18): 2998 - 3006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. Bharucha, P. Tarr, and S. L. Zipursky A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis J. Exp. Biol., October 1, 2008; 211(19): 3103 - 3110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Kaun, M. Chakaborty-Chatterjee, and M. B. Sokolowski Natural variation in plasticity of glucose homeostasis and food intake J. Exp. Biol., October 1, 2008; 211(19): 3160 - 3166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Li, R. Predel, S. Neupert, F. Hauser, Y. Tanaka, G. Cazzamali, M. Williamson, Y. Arakane, P. Verleyen, L. Schoofs, et al. Genomics, transcriptomics, and peptidomics of neuropeptides and protein hormones in the red flour beetle Tribolium castaneum Genome Res., January 1, 2008; 18(1): 113 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Meunier, Y. H. Belgacem, and J.-R. Martin Regulation of feeding behaviour and locomotor activity by takeout in Drosophila J. Exp. Biol., April 15, 2007; 210(8): 1424 - 1434. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
