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Articles in PresS, published online ahead of print August 29, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00172.2002
Submitted on March 18, 2002
Accepted on August 13, 2002
1 Department of Pediatrics, Mattel Children's Hospital, David Geffen School of Medicine @ UCLA, Los Angeles, CA, USA
2 Department of Pediatrics, The University of Arizona College of Medicine, Tucson, AZ, USA
3 Department of Microbiology and Immunology, The Universitiy of Arizona College of Medicine, Tuscon, AZ, USA
4 Department of Pediatrics, University of California at Davis, Sacramento, CA, USA
* To whom correspondence should be addressed. E-mail: rlane{at}mednet.ucla.edu.
Milk-borne Insulin-Like Growth Factors (IGF) enhance nutrient absorption in the immature intestine, which is characterized by low levels of glucose oxidation. We therefore hypothesized that feeding a rat milk substitute (RMS) devoid of growth factors to rat pups would lower serum glucose levels relative to dam-fed control rats, and that supplementation of RMS with physiological doses of either IGF-I or IGF-II would normalize serum glucose levels via increased jejunal glucose transporter 2 (GLUT2) and high affinity Na+-glucose co-transporter (SGLT1) expression. We found lower serum glucose concentrations in RMS-fed pups; in contrast, serum glucose levels in the IGF supplemented pups were similar to those of dam fed controls. RT-PCR and laser scanning confocal microscopy similarly demonstrated that IGF supplementation increased expression of jejunal glucose transporters. Further experiments demonstrated that IGF supplementation altered mRNA levels of key mitochondrial enzymes without altering jejunal lactase activity. We conclude that IGF-I and IGF-II supplementation increases serum glucose levels in the immature rat pup fed artificial formula and alters gene expression of the jejunal glucose transporters.
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