AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (June 27, 2002). doi:10.1152/ajpregu.00173.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/4/R869    most recent
00173.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Papaiconomou, C.
Right arrow Articles by Johnston, M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Papaiconomou, C.
Right arrow Articles by Johnston, M.

Articles in PresS, published online ahead of print June 27, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00173.2002
Submitted on March 18, 2002
Accepted on June 18, 2002

Does neonatal cerebrospinal fluid absorption occur via arachnoid projections or extracranial lymphatics?

Christina Papaiconomou1, Radenka Bozanovic-Sosic1, Andrei Zakharov1, and Miles Johnston1*

1 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Neuroscience Research, Sunnybrook & Women's College Health Sciences Centre, Toronto, Ontario, Canada

* To whom correspondence should be addressed. E-mail: miles.johnston{at}swchsc.on.ca.

Arachnoid villi and granulations are thought to represent the primary sites where cerebrospinal fluid (CSF) is absorbed. However, these structures do not appear to exist in the fetus, but begin to develop around the time of birth and increase in number with age. Using a constant pressure perfusion system in 2-6 day old lambs, we observed that global CSF transport (0.012 ± 0.003 ml.min-1.cm H2O-1) and CSF outflow resistance (96.5 ± 17.8 cm H2O.ml-1.min) were very similar to comparable measures in adult animals despite the relative paucity of arachnoid villi at this stage of development. In the neonate, the recovery patterns of a radioactive protein CSF tracer in various lymph nodes and tissues indicated that CSF transport occurred through multiple lymphatic pathways. An especially important route was transport through the cribriform plate into extracranial lymphatics located in the nasal submucosa. To investigate the importance of the cribriform route in cranial CSF clearance, the cranial CSF compartment was isolated surgically from its spinal counterpart. When the cribriform plate was sealed extracranially under these conditions, CSF transport was impaired significantly. These data demonstrate an essential function for lymphatics in neonatal CSF transport and imply that arachnoid projections may play a limited role earlier in development.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Nagra, J. Li, J. P. McAllister II, J. Miller, M. Wagshul, and M. Johnston
Impaired lymphatic cerebrospinal fluid absorption in a rat model of kaolin-induced communicating hydrocephalus
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1752 - R1759.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Nagra, L. Koh, A. Zakharov, D. Armstrong, and M. Johnston
Quantification of cerebrospinal fluid transport across the cribriform plate into lymphatics in rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1383 - R1389.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2002 by the American Physiological Society.