| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Rehabilitation, Laval University, Ste-Foy, Quebec, Canada
2 Divisions of Hematology-Oncology, Department of Medicine, Mount Sinai University, New York, New York, USA
* To whom correspondence should be addressed. E-mail: jerome.frenette{at}crchul.ulaval.ca.
Our objective was to test the hypothesis that endothelial selectins, P- and E-selectins, are necessary for leukocyte migration following muscle injury from unloading/reloading. Mice hindlimbs were suspended for 10d followed by reloading periods of 6 or 24h after which the soleus muscle was dissected. Light microscopic observations showed that macrophages, but not neutrophils, were able to invade soleus muscles in mice deficient in P/E selectins (P/E-/-) during reloading periods. The recruitment efficiency of neutrophils after 6 and 24h of reloading was minimal in P/E-/- mice relative to unloaded animals. The recruitment of macrophages in the soleus muscle was preserved in P/E-/- mice. The concentration of macrophages increased by 8.1-fold compared to unloaded muscles in double-mutant mice after 24h of reloading. The accumulation of macrophages in reloaded muscles did not lead to fiber necrosis. Together, these findings indicate that macrophages can invade skeletal muscle through cellular mechanisms that do not involve P/E selectins during skeletal muscle reloading.
This article has been cited by other articles:
|
|
 |
|
  N. Dumont, K. Lepage, C. H. Cote, and J. Frenette Mast cells can modulate leukocyte accumulation and skeletal muscle function following hindlimb unloading J Appl Physiol, July 1, 2007; 103(1): 97 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yuan, A. Tie, M. Tarnopolsky, and M. Bakovic Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1 Physiol Genomics, September 14, 2006; 26(1): 76 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. McClung, J. M. Davis, M. A. Wilson, E. C. Goldsmith, and J. A. Carson Estrogen status and skeletal muscle recovery from disuse atrophy J Appl Physiol, June 1, 2006; 100(6): 2012 - 2023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Michel, Z. Yuan, S. Ramsubir, and M. Bakovic Choline Transport for Phospholipid Synthesis. Experimental Biology and Medicine, May 1, 2006; 231(5): 490 - 504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Khandoga, J. S. Kessler, H. Meissner, M. Hanschen, M. Corada, T. Motoike, G. Enders, E. Dejana, and F. Krombach Junctional adhesion molecule-A deficiency increases hepatic ischemia-reperfusion injury despite reduction of neutrophil transendothelial migration Blood, July 15, 2005; 106(2): 725 - 733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. X Pizza, J. M Peterson, J. H Baas, and T. J Koh Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice J. Physiol., February 1, 2005; 562(3): 899 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Baker, B. A. St. P. Schneider, A. Kulkarni, G. Sloan, R. Schaub, J. Sypek, and J. G. Cannon P-selectin inhibition suppresses muscle regeneration following injury J. Leukoc. Biol., August 1, 2004; 76(2): 352 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ley Healing without inflammation? Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2003; 285(4): R718 - R719. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
