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Am J Physiol Regul Integr Comp Physiol (December 27, 2002). doi:10.1152/ajpregu.00189.2002
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Submitted on March 28, 2002
Accepted on December 20, 2002

Increased cellular activity in insular cortex of rat after fluid ingestion induced by fluid depletion

Cinithia V. Pastuskovas1, Martin D. Cassell2, Alan Kim Johnson3, and Robert L. Thunhorst4*

1 Department of Psychology, University of Iowa, Iowa City, Iowa, USA
2 Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, USA
3 Department of Psychology, University of Iowa, Iowa City, Iowa, USA; Department of Pharmacology, University of Iowa, Iowa City, Iowa, USA; Cardiovascular Center, University of Iowa, Iowa City, Iowa, USA
4 Department of Psychology, University of Iowa, Iowa City, Iowa, USA; Cardiovascular Center, University of Iowa, Iowa City, Iowa, USA

* To whom correspondence should be addressed. E-mail: thunhors{at}blue.weeg.uiowa.edu.

Insular cortex (IC) receives inputs from multiple sensory systems, including taste, and from receptors that monitor body electrolyte and fluid balance and blood pressure. This work analyzed metabolic activity of IC cells after water and sodium ingestion induced by sodium depletion. Rats were injected with the diuretic, furosemide (10 mg/kg body wt), followed 5 min later by injections of the angiotensin converting enzyme inhibitor, captopril (5 mg/kg body wt). After 90 min, some rats received water and 0.3 M NaCl to drink for 2 h while others did not. A third group had access to water and saline, but was not depleted of fluids. All rats were sacrificed for processing of brain tissue for Fos-immunoreactivity (Fos-ir). Non-deplete animals had weak-to-moderate levels of Fos-ir within subregions of IC. Fluid-deplete rats without fluid access had significantly increased Fos-ir in all areas of IC. Levels of Fos-ir were highest in fluid-deplete rats that drank water and sodium. Fos-ir levels were highest in anterior regions of IC and lowest in posterior regions of IC. These results implicate visceral, taste and/or post-ingestional factors in the increased metabolic activity of cells in IC.




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