The aim was to evaluate whether blockade of angiotensin II effects during renal development modifies the renal response to an increment of plasma aminoacids concentration. It was also examined in anesthetized rats whether the reduction of the renal ability to eliminate an acute volume expansion (VE), elicited by blockade of angiotensin II during renal development, is gender and/or age-dependent. Newborn SD rats were treated with vehicle or an AT1 receptor antagonist (ARA) during postnatal nephrogenesis. Aminoacids infusion induced an increment (P<0.05) of glomerular filtration rate (31±6%) and renal plasma flow (26±5%) in male but not in female vehicle-treated rats. Natriuretic and diuretic responses to aminoacids infusion were similar in male and female vehicle-treated rats. These renal hemodynamics and excretory responses to aminoacids infusion were abolished in ARA-treated rats. Renal responses to VE were evaluated at 3-4 and 9-10 moths of age in vehicle and ARA-treated rats. The VE-induced natriuresis and diuresis were reduced by more than 38% (p<0.05) in 3-4 months old male and female ARA-treated rats. An aged-dependent reduction (p<0.05) in the renal ability to eliminate a VE was found in males but not in females treated with ARA. Our results demonstrate that the renal effects induced by an increment in aminoacids are abolished when angiotensin II effects have been reduced during nephrogenesis. It has also been demonstrated that this reduction of angiotensin II effects elicits an impairment of the renal ability to eliminate an acute VE in males and females, which is aggravated by age only in males.