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Am J Physiol Regul Integr Comp Physiol (July 13, 2006). doi:10.1152/ajpregu.00211.2006
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Submitted on March 24, 2006
Accepted on July 6, 2006

Repeated exposures to daytime bright light increase nocturnal melatonin rise and keep the circadian phase in young subjects under fixed sleep schedule

Nana N Takasu1, Satoko Hashimoto1, Yujiro Yamanaka1, Yusuke Tanahashi1, Ayano Yamazaki1, Sato Honma1, and Ken-ichi Honma1*

1 Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan

* To whom correspondence should be addressed. E-mail: kenhonma{at}med.hokudai.ac.jp.

Effects of two different light intensities during daytime were examined on human circadian rhythms in plasma melatonin, core body temperature and wrist activity under fixed sleep schedule. Sleep qualities by polysomnography and subjective sleepiness were also measured. In the first week under dim light conditions (ca. 10 lx), the onset and peak of nocturnal melatonin rise were significantly delayed, whereas the end of melatonin rise was not changed. The peak level of melatonin rise was not affected. As a result, the width of nocturnal melatonin rise was significantly shortened. In the second week under bright light conditions (ca. 5,000 lx), the phases of nocturnal melatonin rise were not changed furthermore but the peak level was significantly increased. Core body temperature at the initial sleep phase was progressively elevated during the course of dim light exposure, and reached the maximum level at the first night of bright light conditions. Subjective sleepiness was gradually declined in the course of dim light exposure and reached the minimum level at the first day of bright light. These findings indicate that repeated exposures to daytime bright light are effective in controlling the circadian phase and increasing the peak level of nocturnal melatonin rise in plasma, and suggest a close correlation between phase-delay shifts of the onset of nocturnal melatonin rise or of body temperature rhythm and daytime sleepiness.




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