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1 Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA
* To whom correspondence should be addressed. E-mail: irshad.chaudry{at}ccc.uab.edu.
Recent studies have shown that dehydroepiandrosterone (DHEA) administration following trauma-hemorrhage (T-H) improves cardiovascular function and decreases cytokine production in male animals. Although androstenediol, one of the metabolites of DHEA, is reported to have estrogen-like activity, it remains unknown whether androstenediol per se has any salutary effects on cytokines and cardiovascular function following T-H. To examine this effect, male Sprague-Dawley rats underwent laparotomy and were bled to and maintained at a mean arterial blood pressure of 35-40mmHg for ~90min. The animals were resuscitated with 4 times the volume of maximal bleedout volume in the form of Ringer's lactate. Androstenediol (1mg/kg BW intravenously) or vehicle were administered at the end of resuscitation. Twenty-four hrs after resuscitation, cardiac function and organ blood flow were measured by using Sr85-microspheres. Circulating levels of nitrate/nitrite and IL-6 were also determined. Cardiovascular function and organ blood flow were significantly depressed after T-H. However, these parameters were restored by androstenediol treatment. The elevated plasma IL-6 levels following T-H were also lowered by androstenediol treatment. In contrast, plasma levels of nitrate/nitrite were the highest in the androstenediol-treated T-H animals. Since androstenediol administration following T-H decreases cytokine production and improves cardiovascular function, this agent appears to be a novel and useful adjunct for restoring the depressed cardiovascular function and for cytokine production in male following adverse circulatory conditions.
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