| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Anatomy, Fac Medicine UNAM, Mexico, Mexico DF, Mexico
2 Department of Neuroscience, IFC-UNAM, Mexico, Mexico DF, Mexico
* To whom correspondence should be addressed. E-mail: cescobar{at}ifisiol.unam.mx.
The present study was aimed to identify the hypothalamic nuclei involved with food entrainment by using c-Fos like immunoreactivity (c-Fos-IR) as a marker of functional activation. We studied rats entrained 3 weeks to restricted feeding schedules (RF), their ad libitum (AL) controls and the persistence of c-Fos-IR temporal patterns in entrained fasted rats. In addition we included 22 h fasting and 22 h fasting-refeeding groups as controls of fasting and refeeding acute effects. Diurnal patterns of c-Fos-IR were observed in the tuberomammilar nucleus (TM) and suprachiasmatic nucleus (SCN) in AL rats. In all nuclei excepting the SCN and ventromedial nucleus (VMH), restricted feeding schedules imposed a temporal pattern of increased c-Fos-IR around mealtime. An increase in c-Fos-IR prior and following meal time was observed in dorsomedial nucleus (DMH), lateral nucleus (LH), perifornical area (PeF) and TM, and a marked increase in the paraventricular nucleus (PVN) after feeding. Food-entrained c-Fos-IR patterns persisted after 3 days in fasting in DMH, LH and PeF. Present data suggest that FEO might not rely on a single nucleus and rather may be a distributed system constituted of interacting nuclei in which the PVN is mainly involved with the response to signals elicited by food ingestion and therefore with the entraining pathway. We can suggest that the PeF and TM may be involved with the arousal state during food anticipation and the DMH and LH with the time keeping mechanism of FEO or its output.
This article has been cited by other articles:
|
|
 |
|
  H. L. Haas, O. A. Sergeeva, and O. Selbach Histamine in the Nervous System Physiol Rev, July 1, 2008; 88(3): 1183 - 1241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Vujovic, A. J. Davidson, and M. Menaker Sympathetic input modulates, but does not determine, phase of peripheral circadian oscillators Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R355 - R360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Ribeiro, E. Sawa, I. Carren-LeSauter, J. LeSauter, R. Silver, and D. W. Pfaff Two forces for arousal: Pitting hunger versus circadian influences and identifying neurons responsible for changes in behavioral arousal PNAS, December 11, 2007; 104(50): 20078 - 20083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Baez-Ruiz, C. Escobar, R. Aguilar-Roblero, O. Vazquez-Martinez, and M. Diaz-Munoz Metabolic adaptations of liver mitochondria during restricted feeding schedules Am J Physiol Gastrointest Liver Physiol, December 1, 2005; 289(6): G1015 - G1023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Physiological regulation of food intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1438 - R1443. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
