| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print July 11, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00226.2002
Submitted on April 22, 2002
Accepted on July 11, 2002
1 Department of Medicine, UC, San Diego, La Jolla, CA, USA
2 Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
3 Copenhagen Muscle Research Centre, Copenhagen, Denmark
* To whom correspondence should be addressed. E-mail: rrichardson{at}ucsd.edu.
We studied muscle blood flow, muscle oxygen uptake (VO2), net muscle CO uptake, myoglobin (Mb) saturation, and intracellular bioenergetics during incremental single leg knee-extensor exercise in 5 healthy young subjects in conditions of normoxia, hypoxia (H, 11% O2), normoxia + CO (COnorm) and 100% O2 + CO (COhyper). Maximum work rates and VO2max were equally reduced by {dsim}14% in H, COnorm, and COhyper. The reduction in arterial oxygen content (CaO2) ({dsim}20%) resulted in an elevated blood flow (Q) in the CO and H trials. Net muscle CO uptake was attenuated in the CO trials. Supra systolic cuff measurements of the deoxy-Mb signal were not different in terms of the rate of signal rise or maximum signal attained with and without CO. At maximal exercise calculated mean capillary PO2 was most reduced in H and resulted in the lowest Mb-associated PO2. Reductions in ATP, PCr, and pH during H, COnorm, and COhyper occurred earlier during progressive exercise than in normoxia. Thus, the effects of reduced CaO2 due to mild CO poisoning are similar to H.
This article has been cited by other articles:
|
|
 |
|
  A. Siafaka, E. Angelopoulos, K. Kritikos, M. Poriazi, N. Basios, V. Gerovasili, A. Andreou, C. Roussos, and S. Nanas Acute Effects of Smoking on Skeletal Muscle Microcirculation Monitored by Near-Infrared Spectroscopy Chest, May 1, 2007; 131(5): 1479 - 1485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Gore, F. A. Rodriguez, M. J. Truijens, N. E. Townsend, J. Stray-Gundersen, and B. D. Levine Increased serum erythropoietin but not red cell production after 4 wk of intermittent hypobaric hypoxia (4,000-5,500 m) J Appl Physiol, November 1, 2006; 101(5): 1386 - 1393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Richardson, S. Duteil, C. Wary, D. W. Wray, J. Hoff, and P. G. Carlier Human skeletal muscle intracellular oxygenation: the impact of ambient oxygen availability J. Physiol., March 1, 2006; 571(2): 415 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Gore, W. G. Hopkins, and C. M. Burge Errors of measurement for blood volume parameters: a meta-analysis J Appl Physiol, November 1, 2005; 99(5): 1745 - 1758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Schrage, B. W. Wilkins, V. L. Dean, J. P. Scott, N. K. Henry, M. E. Wylam, and M. J. Joyner Exercise hyperemia and vasoconstrictor responses in humans with cystic fibrosis J Appl Physiol, November 1, 2005; 99(5): 1866 - 1871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. P. Wright, P. F. Klawitter, D. F. Iscru, A. J. Merola, and T. L. Clanton Superoxide scavengers augment contractile but not energetic responses to hypoxia in rat diaphragm J Appl Physiol, May 1, 2005; 98(5): 1753 - 1760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Richardson OXYGEN TRANSPORT AND UTILIZATION: AN INTEGRATION OF THE MUSCLE SYSTEMS Advan Physiol Educ, December 1, 2003; 27(4): 183 - 191. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
