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1 Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom
2 Nephrology & Hypertension, UMC Utrecht, Utrecht, Netherlands
3 Clinical Biochemistry, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
4 Pathology, University Medical Centre Utrecht, Utrecht, Netherlands
5 Department of Clinical Biochemistry, University of Cambridge, United Kingdom
6 Department of Clinical Biochemistry, Level 4, AddenbrookeOs Hospital, United Kingdom
* To whom correspondence should be addressed. E-mail: jane.adkins{at}ntlworld.com.
Telomere shortening has been implicated in the aging process and various age-associated disorders including renal disease. Moreover, oxidative stress has been identified as an initiator of accelerated telomere shortening. We have shown previously that maternal protein restriction during lactation leads to reduced renal telomere shortening, reduced albuminuria and increased longevity in rats. Here we address the hypothesis that maternal protein restriction during lactation is nephroprotective and associated with increased expression of anti-oxidative enzymes and decreased age-dependent renal telomere shortening. New born rats were suckled by a dam fed either a control (20% protein) or low protein (8% protein) diet. All animals were weaned onto standard chow. Offspring that had been suckled by protein restricted mothers had reduced albuminuria, NAG (N-acetyl glucosaminidase) and urinary aldosterone excretion. These animals also did not show significant age-dependent renal telomere shortening and hence had significantly longer telomeres at 12 months of age. This lack of renal telomere shortening was associated with increased levels of the anti-oxidant enzymes manganese superoxide dismutase, glutathione peroxidase and glutathione reductase. These findings suggest that, beneficial effects of slow growth during lactation are associated with increased anti-oxidant capacity and prevention of age-dependent telomere shortening in the kidney.
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  M. S. Martin-Gronert, J. L. Tarry-Adkins, R. L. Cripps, J.-H. Chen, and S. E. Ozanne Maternal protein restriction leads to early life alterations in the expression of key molecules involved in the aging process in rat offspring Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R494 - R500. [Abstract] [Full Text] [PDF]
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M. F. Schreuder Combined nephroprotective effect and low nephron endowment as a consequence of postnatal growth restriction in the rat? Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R276 - R276. [Full Text] [PDF]
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J. A. Joles, J. L. Tarry-Adkins, S. Snoeijs, D. M. van der Giezen, R. Goldschmeding, and S. E. Ozanne Reply to: Schreuder Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R277 - R278. [Full Text] [PDF]
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