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1 Department of Psychology, University of Delaware, Newark, DE, USA
* To whom correspondence should be addressed. E-mail: satinoff{at}udel.edu.
We injected old and young rats with lipopolysaccharide (LPS, 50 µg/kg, ip) at two ambient temperatures (Ta, 21 and 31°C). Young rats mounted equivalent fevers at both Tas (peak body temperatures (Tb) 38.3 and 38.7°C, respectively). The Tb of old rats was not different from baseline (37.3°C) after LPS at Ta 21°C, whereas at 31°C their Tb rose to a mean peak of 38.4°C. We also measured the associated thermoregulatory responses using calorimetry. At 21°C young rats developed a fever by increasing both O2 consumption and heat conservation. Old rats did not become febrile, and O2 consumption fell by 15%. Heat loss was the same in old and young rats. At 31°C, young and old rats developed similar fevers with similar increases in heat production and conservation. Our results suggest that the lack of LPS fever in old rats at 21°C is due mainly to the lowered metabolic rate.
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