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Articles in PresS, published online ahead of print September 26, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00247.2002
Submitted on May 3, 2002
Accepted on September 20, 2002
1 Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA
* To whom correspondence should be addressed. E-mail: ney{at}nutrisci.wisc.edu.
The goal of growth factor treatment in patients with short-bowel syndrome (SBS) is to facilitate transition from parenteral to enteral feedings. Ideal use of growth factors would be acute treatment that produces sustained effects. We investigated the ability of acute insulin-like growth factor-I (IGF-I) treatment to facilitate weaning from total parenteral nutrition (TPN) to enteral feeding in a rat model of SBS. Following a 60% jejuno-ileal resection + cecectomy, rats treated with IGF-I or vehicle were maintained exclusively with TPN for 4 days and transitioned to oral feeding. TPN and IGF-I were stopped 7 days after resection and rats were maintained with oral feeding for 10 more days. Rats administered IGF-I had significantly greater serum concentrations of IGF-I and final body weights due to a proportionate increase in carcass lean body mass and fat compared to rats treated with vehicle. Acute IGF-I treatment induced sustained jejunal hyperplasia based on significantly greater concentrations of jejunal mucosal protein and DNA without a change in histology or sucrase activity. These results demonstrate that acute IGF-I facilitates weaning from parenteral to enteral nutrition in association with maintenance of a greater body weight and serum IGF-I concentration in rats with SBS.
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