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Articles in PresS, published online ahead of print July 25, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00248.2002
Submitted on May 6, 2002
Accepted on July 19, 2002
1 Departments of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
* To whom correspondence should be addressed. E-mail: bshade{at}sfbr.org.
The synergy between angiotensin II (ANG II) and aldosterone (ALDO) in the induction of salt appetite, extensively studied in rats, has been tested in baboons. ANG II was infused intracerebroventricularly (ICV) at 0.5 or 1.0 µg/h; ALDO was infused subcutaneously at 20 µg/h. Separate infusions over 7 days had no significant effect on the daily intake of 300 mM NaCl. Concurrent infusions, however, increased daily NaC1 intake ~10-fold and daily water intake ~ 2.5 fold. In addition, the combined infusions caused (i) a reduction in daily food intake, (ii) changes in blood composition indicative of increased vasopressin release, and (iii) changes of urinary excretion rates of cortisol and aldosterone indicative of increased ACTH release. Arterial blood pressure, measured in two baboons, rose during concurrent ANG II and ALDO treatment. These results indicate a potent synergy between central ANG II and peripheral ALDO in stimulating salt appetite in baboons. At the same time, other ANG II specific brain mechanisms concerned with water intake, food intake, vasopressin release, ACTH release, and blood pressure regulation appear to have been activated by the same type of synergy. These central enhancement processes have never been previously demonstrated in primates.
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