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Am J Physiol Regul Integr Comp Physiol (August 7, 2003). doi:10.1152/ajpregu.00254.2003
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Submitted on May 8, 2003
Accepted on August 3, 2003

Effects of central oxytocin receptor blockade on water and saline intake, mean arterial pressure, and c-Fos expression in rats

Douglas A Fitts1*, Simon N Thornton2, Alexandra A Ruhf1, Dannielle K Zierath1, Alan K Johnson3, and Robert L Thunhorst4

1 Department of Psychology, University of Washington, Seattle, WA, USA
2 Department of Psychology, University of Iowa, Iowa City, IA, USA
3 Department of Psychology, University of Iowa, Iowa City, IA, USA; Department of Pharmacology, University of Iowa, Iowa City, IA, USA; The Cardiovascular Center, University of Iowa, Iowa City, IA, USA
4 Department of Psychology, University of Iowa, Iowa City, IA, USA; The Cardiovascular Center, University of Iowa, Iowa City, IA, USA

* To whom correspondence should be addressed. E-mail: dfitts{at}u.washington.edu.

Central injection of angiotensin (ANG) II has been proposed to have dual effects on salt appetite including a direct stimulatory effect and an indirect inhibitory effect through an activation of central oxytocinergic neurons. The inhibition was demonstrated by pretreating rats with central ornithine vasotocin (OVT, oxytocin antagonist) 30 min before a central ANG II injection. The OVT pretreatment produced a large increase in ANG II-induced saline intake. The present paper reports a failure to replicate that influential experiment. However, we also report for the first time that OVT by itself: (1) provokes drinking of both water and saline solution with a latency almost as short as that produced by ANG II; (2) produces a mild pressor response; and (3) increases c-Fos expression in the organum vasculosum laminae terminalis (OVLT) and the median preoptic nucleus (MnPO). Oxytocin activity may provide an inhibitory control of drinking responses as has been suggested, but the inhibition is tonic and includes both water and saline drinking. Inhibition of this tonic activity may stimulate drinking by increasing neural activity in the OVLT and MnPO.




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