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Am J Physiol Regul Integr Comp Physiol (June 27, 2002). doi:10.1152/ajpregu.00266.2002
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Articles in PresS, published online ahead of print June 27, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00266.2002
Submitted on May 13, 2002
Accepted on June 17, 2002

Capsaicin-Sensitive Adrenal Sensory Fibers Participate in Compensatory Adrenal Growth in Rats

Yvonne M Ulrich-Lai1, Daniel J Marek1, and William C Engeland1*

1 Departments of Surgery and Neuroscience, University of Minnesota, Minneapolis, MN, USA

* To whom correspondence should be addressed. E-mail: engel002{at}tc.umn.edu.

Compensatory adrenal growth, in which one gland undergoes hyperplasia after removal of the other, is mediated by a neural reflex. In the present studies, a method employing capsaicin to selectively remove adrenal sensory fibers was developed and applied to determine whether adrenal capsaicin-sensitive fibers participate in compensatory adrenal growth. The splanchnic nerves of anesthetized male rats were treated with capsaicin or vehicle. Capsaicin treatment selectively removed adrenal CGRP-positive fibers. One week after drug treatment, rats underwent left adrenalectomy or sham surgery and recovered for 5 days. Capsaicin treatment bilaterally or to the left splanchnic nerve alone (i.e. the afferent nerve in the reflex) impaired compensatory adrenal growth at 5 days compared to vehicle controls, whereas capsaicin treatment to the right splanchnic nerve alone did not affect growth. Moreover, left adrenalectomy induced cFos immunolabeling in ipsilateral dorsal spinal cord that was prevented by capsaicin treatment. These data suggest that adrenal capsaicin-sensitive afferent nerves participate in compensatory adrenal growth, and that this effect is primarily on the afferent limb of the reflex.




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