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1 Department of Medicine, Royal Adelaide Hospital, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia
2 Department of Gastroenterology, University Hospital, Utrecht, The Netherlands
3 School of Pharmacy, University of Otago, Dunedin, New Zealand
* To whom correspondence should be addressed. E-mail: christine.feinle{at}adelaide.edu.au.
We have recently reported that intraduodenal infusion of lauric acid (C12) (at 0.375 kcal/min, 106 mM) stimulates isolated pyloric pressure waves (IPPWs), inhibits antral and duodenal pressure waves (PWs), stimulates the release of cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), and suppresses energy intake, and that these effects are much greater than those seen in response to isocaloric decanoic acid (C10) infusion. Administration of C12 was, however, associated with nausea, confounding interpretation of the results. The aim of this study was to evaluate the effects of different intraduodenal doses of C12 on antropyloroduodenal (APD) motility, plasma CCK and GLP-1 concentrations, appetite and energy intake. 13 healthy males were studied on four days in double-blind, randomised, fashion. APD pressures, plasma CCK and GLP-1 concentrations and appetite perceptions were measured during 90 minute intraduodenal infusion of C12 at either (i) 0.1 (14 mM), (ii) 0.2 (28 mM) or (iii) 0.4 (56 mM) kcal/min, or (iv) saline (control) (rate: 4 ml/min). Energy intake was determined at a buffet meal immediately following the infusion. C12 dosedependently stimulated IPPWs, decreased antral and duodenal motility, and stimulated secretion of CCK and GLP-1 (r > 0.4, P < 0.05 for all). C12 at 0.4 kcal/min suppressed energy intake compared with control, C12 (0.1) and C12 (0.2) (P < 0.05). These effects were observed in the absence of nausea. In conclusion, intraduodenal C12 dose-dependently modulated APD motility and gastrointestinal hormone release in healthy male subjects, while effects on energy intake were only apparent with the highest dose infused (0.4 kcal/min), possibly because only at this dose modulation of antropyloroduodenal motility and gastrointestinal hormone secretion was sufficient for a suppressant effect on energy intake. These effects occurred in the absence of nausea.
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