| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
-glucan on innate immune function and susceptibility to respiratory infection
1 Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
2 Department of Pathology and Microbiology, School of Medicine, University of South Carolina, Columbia, SC, USA
* To whom correspondence should be addressed. E-mail: jmdavis{at}sc.edu.
Both moderate exercise and the soluble oat fiber 
-glucan can increase immune function and decrease risk of infection, but no information exists on their possible combined effects. This study tested the effects of moderate exercise and oat -glucan on respiratory infection, macrophage anti-viral resistance and NK cytotoxicity. Mice were assigned to four groups: Ex-H2O, Ex-OG, Con-H2O, or Con-OG. Oat -glucan was fed in the drinking water for 10 days prior to intranasal inoculation of HSV-1 or sacrifice. Exercise consisted of treadmill running (1h/day) for 6 days. Macrophage resistance to HSV-1 was increased with both Ex and OG, whereas NK cytotoxicity was only increased with Ex. Ex was also associated with a 45% and 38% decrease in morbidity and mortality, respectively. Mortality was also decreased with OG but this effect did not reach statistical significance. No additive effects of Ex and OG were found. These data confirm a positive effect of both moderate exercise and oat -glucan on immune function, but only moderate exercise was associated with a significant reduction in the risk of URTI in this model.
This article has been cited by other articles:
|
|
 |
|
  J. M. Davis, E. A. Murphy, J. L. McClellan, M. D. Carmichael, and J. D. Gangemi Quercetin reduces susceptibility to influenza infection following stressful exercise Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R505 - R509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Murphy, J. M. Davis, A. S. Brown, M. D. Carmichael, J. A. Carson, N. Van Rooijen, A. Ghaffar, and E. P. Mayer Benefits of oat {beta}-glucan on respiratory infection following exercise stress: role of lung macrophages Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1593 - R1599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Yeh, H. Chuang, L.-W. Lin, C.-Y. Hsiao, P.-W. Wang, and K. D. Yang Tai Chi Chuan Exercise Decreases A1C Levels Along With Increase of Regulatory T-Cells and Decrease of Cytotoxic T-Cell Population in Type 2 Diabetic Patients Diabetes Care, March 1, 2007; 30(3): 716 - 718. [Full Text] [PDF]
|
|
|
|
 |
|
 S-H Yeh, H Chuang, L-W Lin, C-Y Hsiao, and H L Eng Regular tai chi chuan exercise enhances functional mobility and CD4CD25 regulatory T cells. Br. J. Sports Med., March 1, 2006; 40(3): 239 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Murphy, J. M. Davis, A. S. Brown, M. D. Carmichael, N. Van Rooijen, A. Ghaffar, and E. P. Mayer Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1354 - R1358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Murphy, J. M. Davis, A. S. Brown, M. D. Carmichael, E. P. Mayer, and A. Ghaffar Effects of moderate exercise and oat {beta}-glucan on lung tumor metastases and macrophage antitumor cytotoxicity J Appl Physiol, September 1, 2004; 97(3): 955 - 959. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
