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Am J Physiol Regul Integr Comp Physiol (October 9, 2003). doi:10.1152/ajpregu.00304.2003
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Submitted on June 2, 2003
Accepted on October 7, 2003

Effects of moderate exercise and oat {beta}-glucan on innate immune function and susceptibility to respiratory infection

J. Mark Davis1*, Elizabeth A Murphy1, Adrienne S Brown1, Martin D Carmichael1, Abdul Ghaffar2, and Eugene P Mayer2

1 Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
2 Department of Pathology and Microbiology, School of Medicine, University of South Carolina, Columbia, SC, USA

* To whom correspondence should be addressed. E-mail: jmdavis{at}sc.edu.

Both moderate exercise and the soluble oat fiber {beta}-glucan can increase immune function and decrease risk of infection, but no information exists on their possible combined effects. This study tested the effects of moderate exercise and oat {beta}-glucan on respiratory infection, macrophage anti-viral resistance and NK cytotoxicity. Mice were assigned to four groups: Ex-H2O, Ex-O{beta}G, Con-H2O, or Con-O{beta}G. Oat {beta}-glucan was fed in the drinking water for 10 days prior to intranasal inoculation of HSV-1 or sacrifice. Exercise consisted of treadmill running (1h/day) for 6 days. Macrophage resistance to HSV-1 was increased with both Ex and O{beta}G, whereas NK cytotoxicity was only increased with Ex. Ex was also associated with a 45% and 38% decrease in morbidity and mortality, respectively. Mortality was also decreased with O{beta}G but this effect did not reach statistical significance. No additive effects of Ex and O{beta}G were found. These data confirm a positive effect of both moderate exercise and oat {beta}-glucan on immune function, but only moderate exercise was associated with a significant reduction in the risk of URTI in this model.




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