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Am J Physiol Regul Integr Comp Physiol (September 27, 2002). doi:10.1152/ajpregu.00331.2002
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Articles in PresS, published online ahead of print September 26, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00331.2002
Submitted on June 11, 2002
Accepted on September 24, 2002

Decrease of food intake by a melanocortin-4 receptor agonist (MTII) in Siberian hamsters in long and short photoperiods

Sandrine Schuhler1*, Tracey L Horan1, Michael H Hastings2, Julian G Mercer3, Peter J Morgan3, and Francis J Ebling1

1 School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom
2 Neurobiology Division, Laboratory of Molecular Biology, Cambridge, United Kingdom
3 Molecular Neuroendocrinology Group, The Rowett Research Institute, Aberdeen, United Kingdom

* To whom correspondence should be addressed. E-mail: alex.schuhler{at}nottingham.ac.uk.

We investigated the role of the hypothalamic melanocortin system in the regulation of food intake in the Siberian hamster which shows a profound seasonal decrease in food intake and body weight in short photoperiod (SP). In male hamsters maintained in long photoperiod (LP), icv injection of MTII just before lights off significantly decreased food intake relative to vehicle treatment over the 6 h observation period. Similar effects were observed in age-matched hamsters after exposure to a short daylength for nine weeks, when body weight had significantly decreased. There was no clear difference in either the magnitude of response or the dose required for half-maximal inhibition of food intake in hamsters in SP compared to those in LP. MTII significantly increased grooming in both LP and SP. Our results indicate that the melanocortin system is a potent short-term regulator of food intake. However, the lack of differential response or sensitivity to MTII treatment in the obese (LP) vs lean (SP) states do not support the hypothesis that changes in this melanocortin pathway underlie the long-term decrease in food intake which occurs in this seasonal model.




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