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1 Dept. Cell & Molecular Physiology, Univ. North Carolina Chapel Hill, Chapel Hill, North Carolina, United States
* To whom correspondence should be addressed. E-mail: just{at}med.unc.edu.
Autoregulation of renal blood flow (RBF) is caused by the myogenic response (MR), tubuloglomerular feedback (TGF), and a third regulatory mechanism that is independent of TGF but slower than MR. The underlying cause of the third regulatory mechanism remains unclear; possibilities include ATP, Ang II or a slow component of MR. Other mechanisms, which, however, exert their action through modulation of MR and TGF are pressure-dependent change of proximal tubular reabsorption, resetting of RBF and TGF, as well as modulating influences of Angiotensin II (Ang II) and nitric oxide (NO). MR requires <10 s for completion in the kidney and normally follows first-order kinetics without rate-sensitive components. TGF takes 30-60 s and shows spontaneous oscillations at 0.025-0.033 Hz. The third regulatory component requires 30-60 s; changes in proximal tubular reabsorption develop over 5 min and more slowly for up to 30 min, while RBF and TGF resetting stretch out over 20-60 min. Due to these kinetic differences, the relative contribution of the autoregulatory mechanisms determines the amount and spectrum of pressure fluctuations reaching glomerular and postglomerular capillaries and thereby potentially impinge on filtration, reabsorption, medullary perfusion, and hypertensive renal damage. Under resting conditions, MR contributes ~50% to overall RBF autoregulation, TGF 35-50%, and the third mechanism less than 15%. NO attenuates the strength, speed and contribution of MR, whereas Ang II does not modify the balance of the autoregulatory mechanisms.
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