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Articles in PresS, published online ahead of print November 7, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00349.2002
Submitted on June 13, 2002
Accepted on November 4, 2002
1 Pelvipharm, Gif sur Yvette, France
2 Department of Internal Medicine, Broussais Hospital, Paris, France
3 Pelvipharm, Gif sur Yvette, France; Groupe de recherche en Urologie, Medical University of Paris-South, Cedex, France
* To whom correspondence should be addressed. E-mail: giuliano{at}cyber-sante.org.
Hypertensive men have a higher prevalence of erectile dysfunction (ED) than the general population. Experimental evidence of ED in hypertensive animals is scarce. This study evaluates the erectile function of spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY) in vivo by the increase in intracavernosal pressure (ICP) following electrical stimulation of the cavernous nerve (CN) and by isometric tension studies on corporal strips. Frequency-dependent erectile responses to CN stimulations were reduced in SHR. Phenylephrine induced lower corporal contractions in SHR although pD2 values were similar to WKY. Endothelium-dependent relaxations to ACh were significantly impaired in SHR and indomethacin improved these relaxations in both WKY and SHR, the latter thus reaching values similar to WKY. Corporal relaxations to sodium nitroprusside were enhanced in SHR. Thus, a dysfunctional 
-adrenergic contraction of the corporal smooth muscle, an increased cyclo-oxygenase-dependent constrictor tone and/or a defect in endothelium-dependent reactivity are associated with the altered erectile mechanisms in SHR. Drugs targeting endothelial dysfunction may delay the occurrence of ED as a complication of hypertension.
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