AJP - Regu Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (July 20, 2006). doi:10.1152/ajpregu.00353.2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
292/2/R731    most recent
00353.2006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iliescu, R.
Right arrow Articles by Reckelhoff, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iliescu, R.
Right arrow Articles by Reckelhoff, J. F.
Submitted on May 25, 2006
Accepted on July 17, 2006

Impact of androgen-induced oxidative stress on hypertension in male SHR

Radu Iliescu1, Valeria E Cucchiarelli1, Licy L. Yanes1, Joshua W. Iles1, and Jane F. Reckelhoff1*

1 Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States

* To whom correspondence should be addressed. E-mail: jreckelhoff{at}physiology.umsmed.edu.

Men have higher blood pressure than women, and androgens and oxidative stress have been implicated as playing roles in this sexual dimorphism. The SHR is an animal model of both androgen- and oxidative stress-mediated hypertension. Therefore, the present studies were performed to test the hypothesis that androgens cause hypertension in SHR in part by stimulating superoxide production via NADPH oxidase. Castration of male SHR reduced blood pressure by 15% and attenuated both basal and NADPH-stimulated superoxide production in kidney cortical homogenates. Expression of p47phox and gp91phox but not p22phox subunits of NADPH oxidase were significantly lower in kidney cortex from castrated males compared to intact males. Moreover, inhibition of NADPH oxidase with apocynin caused approximately 15 mm Hg reduction in blood pressure and reduced basal and NADPH-stimulated superoxide production in intact male SHR, but had no effect on blood pressure or superoxide production in castrated males. These data support the hypothesis that androgens cause oxidative stress and thereby increase blood pressure in male SHR via an NADPH oxidase-dependent mechanism.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
Q. Xu, A. Prabhu, S. Xu, M. B. Manigrasso, and C. Maric
Dose-dependent effects of dihydrotestosterone in the streptozotocin-induced diabetic rat kidney
Am J Physiol Renal Physiol, August 1, 2009; 297(2): F307 - F315.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
O. Tornavaca, G. Pascual, M.L. Barreiro, M.T. Grande, A. Carretero, M. Riera, E. Garcia-Arumi, B. Bardaji, M. Gonzalez-Nunez, M.A. Montero, et al.
Kidney Androgen-Regulated Protein Transgenic Mice Show Hypertension and Renal Alterations Mediated by Oxidative Stress
Circulation, April 14, 2009; 119(14): 1908 - 1917.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Tian, R. S. Moore, W. E. Phillips, L. Lin, S. Braddy, J. S. Pryor, R. L. Stockstill, M. D. Hughson, and R. D. Manning Jr.
NADPH oxidase contributes to renal damage and dysfunction in Dahl salt-sensitive hypertension
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1858 - R1865.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Ebrahimian, M. R. Sairam, E. L. Schiffrin, and R. M. Touyz
Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause
Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1481 - H1488.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Lopez-Ruiz, J. Sartori-Valinotti, L. L. Yanes, R. Iliescu, and J. F. Reckelhoff
Sex differences in control of blood pressure: role of oxidative stress in hypertension in females
Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H466 - H474.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
Q. Xu, C. C. Wells, J. H. Garman, L. Asico, C. S. Escano, and C. Maric
Imbalance in Sex Hormone Levels Exacerbates Diabetic Renal Disease
Hypertension, April 1, 2008; 51(4): 1218 - 1224.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
R. Iliescu and J. F. Reckelhoff
Sex and the Kidney
Hypertension, April 1, 2008; 51(4): 1000 - 1001.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Tian, R. S. Moore, S. Braddy, R. A. Rose, J.-W. Gu, M. D. Hughson, and R. D. Manning Jr.
Interactions between oxidative stress and inflammation in salt-sensitive hypertension
Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3388 - H3395.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Denton and C. Baylis
Physiological and molecular mechanisms governing sexual dimorphism of kidney, cardiac, and vascular function
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R697 - R699.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2006 by the American Physiological Society.