| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Division of Reproductive Health, Endocrinology and Development, Kings College London, London, United Kingdom
2 Rowett Research Institute, Aberdeen, United Kingdom; Division of Reproductive Health, Endocrinology and Development, Kings College London, London, United Kingdom
3 Obstetrics and Gynaecology, Katholieke University Leuven, Leuven, Belgium
4 Institute of Child Health, University College London, London, United Kingdom
5 Rowett Research Institute, Aberdeen, United Kingdom
6 Centre for the Developmental Origins of Health and Disaese (DOHaD), Princess Anne Hospital, Southampton, United Kingdom
* To whom correspondence should be addressed. E-mail: paul.taylor{at}kcl.ac.uk.
We have previously reported prenatal and suckling exposure to a maternal diet rich in animal fat leads to cardiovascular dysfunction in the young adult rat offspring with susequent development of dyslipidaemia and hyperglycaemia. We have further investigated glucose homeostasis in adult female offspring by euglycaemic hyperinsulinaemic clamp and by dynamic assessment of glucose stimulated insulin secretion in isolated perifused pancreatic islet cells. Additionally, given the link between reduced mitochondrial DNA content (mtDNA) and the development of type 2 diabetes mellitus, we have measured mtDNA in organs from young adult animals. Sprague-Dawley rats were fed a diet rich in animal fat or normal chow throughout pregnancy and weaning. Infusion of 5 mU insulin.kg-1.min-1 resulted in a higher steady state plasma insulin concentration in 1 year old offspring of fat-fed dams (OHF) versus (n=4) versus offspring of control dams (OC, n=4, P < 0.01). Glucose stimulated insulin secretion in isolated islets from 9 month old OHF was significantly reduced compared to OC (n=4, P<0.05). Transmission electron microscopy showed altered insulin secretory granule morphology in OHF pancreatic 
-cells. Kidney mtDNA was reduced in 3month old OHF (OC, n=10, 1.05±0.19 versus OHF, n=10, 0.66±0.06, P<0.05). At 6months, gene chip micro-array of OHF aorta showed reduced expression of the mitochondrial genome. Prenatal/suckling exposure to a diet rich in animal fat leads to whole body insulin resistance and pancreatic b-cell dysfunction in adulthood which is preceded by reduced tissue mitochondrial DNA content and altered mitochondrial gene expression.
This article has been cited by other articles:
|
|
 |
|
  G.-Q. Chang, V. Gaysinskaya, O. Karatayev, and S. F. Leibowitz Maternal High-Fat Diet and Fetal Programming: Increased Proliferation of Hypothalamic Peptide-Producing Neurons That Increase Risk for Overeating and Obesity J. Neurosci., November 12, 2008; 28(46): 12107 - 12119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Armitage, S. Gupta, C. Wood, R. I. Jensen, A.-M. Samuelsson, W. Fuller, M. J. Shattock, L. Poston, and P. D. Taylor Maternal dietary supplementation with saturated, but not monounsaturated or polyunsaturated fatty acids, leads to tissue-specific inhibition of offspring Na+,K+-ATPase J. Physiol., October 15, 2008; 586(20): 5013 - 5022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Shankar, A. Harrell, X. Liu, J. M. Gilchrist, M. J. J. Ronis, and T. M. Badger Maternal obesity at conception programs obesity in the offspring Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R528 - R538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-M. Samuelsson, P. A. Matthews, M. Argenton, M. R. Christie, J. M. McConnell, E. H.J. M. Jansen, A. H. Piersma, S. E. Ozanne, D. F. Twinn, C. Remacle, et al. Diet-Induced Obesity in Female Mice Leads to Offspring Hyperphagia, Adiposity, Hypertension, and Insulin Resistance: A Novel Murine Model of Developmental Programming Hypertension, February 1, 2008; 51(2): 383 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ferezou-Viala, A.-F. Roy, C. Serougne, D. Gripois, M. Parquet, V. Bailleux, A. Gertler, B. Delplanque, J. Djiane, M. Riottot, et al. Long-term consequences of maternal high-fat feeding on hypothalamic leptin sensitivity and diet-induced obesity in the offspring Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1056 - R1062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Sedova, O. Seda, L. Kazdova, B. Chylikova, P. Hamet, J. Tremblay, V. Kren, and D. Krenova Sucrose feeding during pregnancy and lactation elicits distinct metabolic response in offspring of an inbred genetic model of metabolic syndrome Am J Physiol Endocrinol Metab, May 1, 2007; 292(5): E1318 - E1324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Armitage, A. Ishibashi, A. A. Balachandran, R. I. Jensen, L. Poston, and P. D. Taylor Placental-Perinatal: Programmed aortic dysfunction and reduced Na+,K+-ATPase activity present in first generation offspring of lard-fed rats does not persist to the second generation Exp Physiol, May 1, 2007; 92(3): 583 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Taylor and L. Poston Developmental programming of obesity in mammals Exp Physiol, March 1, 2007; 92(2): 287 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D I. Phillips External influences on the fetus and their long-term consequences Lupus, November 1, 2006; 15(11): 794 - 800. [Abstract] [PDF]
|
|
|
|
|
|
M. Srinivasan, S. D. Katewa, A. Palaniyappan, J. D. Pandya, and M. S. Patel Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood Am J Physiol Endocrinol Metab, October 1, 2006; 291(4): E792 - E799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Persson From clinical insights to new therapies Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R124 - R125. [Full Text] [PDF]
|
|
|
|
|
|
J. Schwartz and J. L. Morrison Impact and mechanisms of fetal physiological programming Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R11 - R15. [Full Text] [PDF]
|
|
|
|
|
|
I. Y. Khan, V. Dekou, G. Douglas, R. Jensen, M. A. Hanson, L. Poston, and P. D. Taylor A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R127 - R133. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
