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1 Department of Psychology and the Gonda (Goldschmeid) Brain Research Center, Bar-Ilan University, Ramat Gan, Israel
2 Department of Psychiatry, Joan and Sanford I. Weill Medical College of Cornell University and New York-Presbyterian Hospital, Westchester Division, White Plains, NY, USA
* To whom correspondence should be addressed. E-mail: weller{at}mail.biu.ac.il.
Otsuka Long Evans Tokushima fatty (OLETF) rats are a strain of Long Evans Tokushima Otsuka (LETO) rats that do not express CCK-1 receptors, developing in adulthood, hyperphagia, obesity, and NIDDM. We examined weight gain and meal patterns during a 30-min independent ingestion test on postnatal days 2-4 and again on days 9-11 in OLETF and LETO rat pups. OLETF pups were significantly heavier compared to their LETO controls at both ages and they consumed significantly more of the sweet milk diet. The difference in intake can be attributed to a significant increase in meal size and duration. Number of clusters and bursts of licking within a meal was greater in OLETF rat pups, with no difference between strains in burst and cluster size. Inter-lick-interval (ILI) was not significantly different between OLETF and LETO. This measure decreased on days 9-11 compared to days 2-4 in both strains. Latency to start feeding was significantly shorter on days 2-4 in OLETF vs. LETO pups, but this difference disappeared at the second test at the older age. Two to four days old OLETF pups consumed a larger volume of milk during the first minute of feeding, and their initial lick rate and decay of lick rate were significantly larger compared to their LETO controls. Lack of CCK-1 receptors, or other OLETF-related abnormalities, therefore resulted in a satiation deficit, leading to increased meal size, hyperphagia and increased weight gain as early as 2-4 postnatal days.
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  M. Schroeder, L. Shbiro, O. Zagoory-Sharon, T. H. Moran, and A. Weller Toward an animal model of childhood-onset obesity: follow-up of OLETF rats during pregnancy and lactation Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R224 - R232. [Abstract] [Full Text] [PDF]
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B. C. De Jonghe, A. Hajnal, and M. Covasa Conditioned preference for sweet stimuli in OLETF rat: effects of food deprivation Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1819 - R1827. [Abstract] [Full Text] [PDF]
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 B. C. De Jonghe, A. Hajnal, and M. Covasa Decreased gastric mechanodetection, but preserved gastric emptying, in CCK-1 receptor-deficient OLETF rats Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G640 - G649. [Abstract] [Full Text] [PDF]
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