| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print November 7, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00399.2002
Submitted on July 3, 2002
Accepted on October 28, 2002
1 Psychiatry, University of Cincinnati, Cincinnati, OH, USA
2 Biomedical Sciences, University of Cincinnati, Cincinnati, OH, USA; Cell Biology, Neurobiology and Anatomy, University of Cincinnati, Cincinnati, OH, USA
* To whom correspondence should be addressed. E-mail: debbie.clegg{at}uc.edu.
The lateral hypothalamus (LH) has a critical role in the control of feeding and drinking. Melanin concentrating hormone (MCH) is an orexigenic peptidergic neurotransmitter produced primarily in the LH, and Agouti-Related Protein (AgRP) is an orexigenic peptidergic neurotransmitter produced exclusively in the arcuate (ARC), an area that innervates the LH. We assessed drinking and eating after the 3rd ventricular (i3vt) administration of MCH and AgRP. MCH (2.5, 5, 10 µg, i3vt) significantly increased food as well as water intake over 4 hrs when administered during either the light or the dark portion of the day/night cycle. When MCH (5 µg) was administered to rats with access to water but no food, they drank significantly more water than when given the vehicle. AgRP (7 µg, i3vt), on the other hand, increased water intake, but only in proportion to food intake during the dark and the light, and water intake was not increased following i3vt AgRP in the absence of food. Hence, in contrast to AgRP, MCH elicits increased water intake independent of food intake. These results are consistent with historical data linking activity of the LH with water as well as food intake.
This article has been cited by other articles:
|
|
 |
|
  J.-P. Baird, C. Rios, J. L. Loveland, J. Beck, A. Tran, and C. E. Mahoney Effects of hindbrain melanin-concentrating hormone and neuropeptide Y administration on licking for water, saccharin, and sucrose solutions Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R329 - R343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Eric Hu, J. A. Wos, M. E. Dowty, P. M. Suchanek, W. Ji, J. B. Chambers, S. C. Benoit, D. J. Clegg, and O. Reizes Small-Molecule Melanin-Concentrating Hormone-1 Receptor Antagonists Require Brain Penetration for Inhibition of Food Intake and Reduction in Body Weight J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 206 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Baird, C. Rios, N. E. Gray, C. E. Walsh, S. G. Fischer, and A. L. Pecora Effects of melanin-concentrating hormone on licking microstructure and brief-access taste responses Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1265 - R1274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Clegg, L. M. Brown, S. C. Woods, and S. C. Benoit Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes, April 1, 2006; 55(4): 978 - 987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Jeon, R. L. Bradley, E. G. Kokkotou, F. E. Marino, X. Wang, P. Pissios, and E. Maratos-Flier MCH-/- Mice Are Resistant to Aging-Associated Increases in Body Weight and Insulin Resistance Diabetes, February 1, 2006; 55(2): 428 - 434. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
