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Articles in PresS, published online ahead of print August 1, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00402.2002
Submitted on July 8, 2002
Accepted on July 27, 2002
* To whom correspondence should be addressed. E-mail: levin{at}umdnj.edu.
The impact of maternal obesity on brain monoamine function in adult offspring of dams selectively bred to express diet-induced obesity (DIO) or diet-resistance (DR) was assessed by making dams obese or lean during gestation and lactation. After 12wk on chow and 4wk on a 31% fat diet, offspring hypothalamic nucleus size and binding of 3H nisoxetine binding to norepinephrine transporters (NET) and 3H paroxetine binding to serotonin transporters (SET) was measured. Offspring of obese DIO dams became more obese than all other groups but maternal obesity did not alter weight gain in DR offspring (25). Maternal obesity was associated with 10-17% enlargement of ventromedial (VMN) and dorsomedial nuclei in both DIO and DR offspring. Offspring of obese DIO dams had 25-88% lower NET binding in the paraventricular (PVN), arcuate, VMN and the central amygdalar nuclei, while offspring of obese DR dams had 43-67% higher PVN and 90% lower VMN NET binding and a generalized increase in SET binding across all hypothalamic areas compared to other groups. Thus, maternal obesity was associated with alterations in offspring brain monoamine metabolism which varied as a function of genotype and the development of offspring obesity.
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